Aire regulates negative selection of organ-specific T cells

By A. Liston, S. Lesage, Judith Wilson, L. Peltonen, C. Goodnow. Nature Immunology, 2003

831 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/85ea3a315dd7c609ab45141896627096932b910e

How researchers see this paper

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In Endocrinology, Diabetes and Metabolism

1. P. Greenberg
2. A. Schietinger

In Genetics

1. D. Mathis
2. Shimon Sakaguchi
3. C. Benoist

In Immunology

1. Shimon Sakaguchi
2. T. Nomura
3. M. Ono
4. D. Mathis
5. C. Benoist
6. L. Klein
7. L. Romani
8. S. Jameson

Citations in the corpus

• Type 1 diabetes: etiology, immunology, and therapeutic strategies. (2011, background): “This reduced expression allows autoreactive T cells to escape into the periphery, because it interferes with thymic deletion (16, 246).”
• Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells (2007, background): “Evidence suggests that tissue-specific antigens expressed in mTECs contribute to central tolerance in an essential way by inducing recessive tolerance (such as clonal deletion of autoreactive thymocytes”
• Immunity to fungal infections (2011, background): “CMC, although encompassing various clinical entities, has been associated with autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy — a condition in which the mutated gene has been shown to be involved in the ontogeny of CD25 + T Reg cell”
• Central tolerance: learning self-control in the thymus (2005, background): “and that mutations in the gene encoding AIRE underlie a specific human autoimmune disease, APECE”
• The cellular mechanism of Aire control of T cell tolerance. (2005, methodology): “cells were the same in Aire-positive and -negative hen egg lysozyme (HEL)-specific TCR tg mice ( Liston et al., 2003 ).”
• Cellular and genetic mechanisms of self tolerance and autoimmunity (2005, background): “and a marked failure to delete organ-specific TCRs in the thymus because tissue-specific genes are not switched on in rare medullary thymic epithelial cell”
• Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease (2006, background): “in the medullary epithelial cells, whereas the number and in vitro assessed suppressive activity of natural Tregs are reportedly intact (116, 117).”