Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

By M. Matloubian, C. Lo, Guy Cinamon, Matthew J. Lesneski, Ying Xu, V. Brinkmann, M. L. Allende, R. Proia, J. Cyster. Nature, 2004

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Systemic Immunity is Required for Effective Cancer Immunotherapy (2017, positive): “To segregate the immune response in the tumor from the systemic immune response, we treated animals with FTY720, a ligand of the sphinosine-1-phosphate receptor 1, which is required for immune cells to migrate from the secondary lymphoid organs (Matloubian et al., 2004).”
Tissue-Resident Memory T Cells (2014, background): “S1PR1 downregulation is concomitantly associated with cell surface expression of the C-type lectin CD69 (Cyster and Schwab, 2012; Matloubian et al., 2004; Schober et al., 1999; Shiow et al., 2006; Skon et al., 2013).”
Essential Role for Sphingosine Kinases in Neural and Vascular Development (2005, background): “Recently, numerous studies on S1P have demonstrated its importance in the development of the vascular system (1, 14, 16, 18), the heart (15), and immunity (2, 5, 21) by signaling through a family of G protein-coupled receptors designated S1P1 to S1P5.”