CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.

By L. Ohl, M. Mohaupt, N. Czeloth, G. Hintzen, Z. Kiafard, J. Zwirner, T. Blankenstein, G. Henning, R. Förster. Immunity, 2004

1,093 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/b1e5fbafeddefc0d3524001976b3d21e73bcd782

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Citations in the corpus

• Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 (2007, methodology): “Lymphocytes were isolated from skin, colon (lamina propria) and lung after collegenase D digestion as describe”
• Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells (2012, result): “Based on the comparison of these two tissues and in keeping with the phenotype of migrating DCs in mouse LNs (Ohl et al., 2004), we identified the CD11cHLA-DR population as tissue migratory DCs.”
• Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “In skin-draining LNs, CCR7 is necessary for migration of the dermal langerin-positive DC subset (49).”
• Development and function of dendritic cell subsets. (2014, positive): “All dermal DC populations display CCR7-dependent migration to cutaneous LNs (Henri et al., 2010; Ohl et al., 2004) and all dermal cDC subsets can efficiently present Ags in a MHC-II context (Bedoui et al.”
• The chemokine system in innate immunity. (2015, background): “CCR7 signaling is a common pathway for homeostatic DC migration from diverse peripheral tissues; CCR7 has been shown to be essential for migration of DCs from the skin, lung, and gastrointestinal tract (Ohl et al. 2004; Worbs et al. 2006).”
• The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Upon LPS injection in the periphery, BM CDPs downregulate CXCR4, allowing them to leave the BM, up-regulate CCR7, and home to the LNs, where they differentiate into DCs (249).”
• OMIP-044: 28-color immunophenotyping of the human dendritic cell compartment (2018, background): “Of note, CCR7 has also been shown to be essential for DC migration to draining lymph nodes (22).”
• Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing (2005, background): “Chemokine receptor CCR7 is required for migration of these skin-resident DCs to draining LNs under both steady-state and inflammatory conditions (25, 26).”
• Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions (2009, background): “10 cells i.v. 3 d after intralymphatic injection, T cell proliferation was determined in MLN and peripheral LNs. Injection of CD103+ DC induced proliferation of antigen-specific DO11.”
• Tissue-Resident Memory T Cells (2014, background): “Similarly, dendritic cells upregulate CCR7 after activation in tissues, which then acts in concert with S1PR1 to promote migration to downstream SLOs (Braun et al., 2011; Czeloth et al., 2005; Lamana et al., 2011; Ohl et al., 2004; Saeki et al., 1999).”
• Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma (2016, positive): “Conventional DC LN trafficking is driven by the chemokine receptor CCR7 (Ohl et al., 2004).”
• Dendritic-cell trafficking to lymph nodes through lymphatic vessels (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1236">CCR7 ), to migrate to lymph nodes through peripheral lymphatic vessel”
• Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles (2005, background): “Likely transport mechanisms to the lymph nodes are skin macrophages and dendritic (Langerhans) cells (Ohl et al. 2004; Sato et al. 1998); this raises a question about potential modulation of immune responses, after interaction of these NP-containing macrophages and dendritic cells with T…”
• Visualizing dendritic cell networks in vivo (2004, background): “The subcapsular DCs resembled EYFP cells on serosal surfaces outside the lymph node ( Supplementary Video 7 online), which may suggest that they were recent immigrants from the peripher”