Cellular and molecular mechanisms of mitochondrial function
By L. Osellame, T. Blacker, M. Duchen. Best practice & research. Clinical endocrinology & metabolism, 2012
778 citations recorded by the source corpus.
Mitochondria are membrane bound organelles present in almost all eukaryotic cells. Responsible for orchestrating cellular energy production, they are central to the maintenance of life and the gatekeepers of cell death. Thought to have originated from symbiotic ancestors, they carry a residual genome as mtDNA encoding 13 proteins essential for respiratory chain function. Mitochondria comprise an inner and outer membrane that separate and maintain the aqueous regions, the intermembrane space and the matrix. Mitochondria contribute to many processes central to cellular function and dysfunction including calcium signalling, cell growth and differentiation, cell cycle control and cell death. Mitochondrial shape and positioning in cells is crucial and is tightly regulated by processes of fission and fusion, biogenesis and autophagy, ensuring a relatively constant mitochondrial population. Mitochondrial dysfunction is implicated in metabolic and age related disorders, neurodegenerative diseases and ischemic injury in heart and brain.
Subfields: Clinical Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6c69cb01d3a1aa51ca6bf120705888a9eba4185d
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In Clinical Biochemistry
In Molecular Biology
Citations in the corpus
- Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes (2020, background): “Mitochondrial Dysfunction Mitochondria are present in almost all eukaryotic cells and are responsible for cellular energy production, calcium signaling, and apoptosis (Osellame et al., 2012).”
- Unexpected low‐dose toxicity of the universal solvent DMSO (2014, background): “Calcium cell dysregulation is associated with cell death particularly in muscle and neuronal cells (55).”