Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

By Chengyu Liang, Jong-soo Lee, Kyung-Soo Inn, Michaela U. Gack, Qinglin Li, Esteban A. Roberts, I. Vergne, V. Deretic, P. Feng, C. Akazawa and 1 more. Nature Cell Biology, 2008

804 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/044d064f3334dccf1e911f2f796734c3c3d532ad

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Citations in the corpus

Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “One of these proteins is UVRAG (functionally related to Vps38) (709), which promotes autophagy either by recruiting curvature-sensing BAR-domain containing proteins (317, 1517) or by enhancing fusion of autophagosomes with lysosomes (908).”
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity (2010, background): “In support of this concept, the function of several beclin 1 -related proteins, for example UVRA”
The regulation of autophagy – unanswered questions (2011, background): “, 2007), UV radiation resistance-associated gene (UVRAG) protein (Liang et al., 2008) and Bax-interacting factor 1 (Bif1) (Takahashi et al.”
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages (2009, background): “UVRAG functions in the autophagy maturation process through its binding to Class C VPS, which is involved in the fusion of autophagosomes and lysosome”
Autophagy, Immunity, and Microbial Adaptations (2009, background): “…role in early autophagosomal membrane formation (Axe et al., 2008), the targeting of PI3P–binding proteins such as Atg18 to the autophagic membrane (Obara et al., 2008), the localization of LC3 lipidation (Fujita et al., 2008), and autophagosomal maturation into autolysosomes (Liang et al., 2008).”
Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “A recent study shows that autophagosome–endosome fusion is enhanced by components of the HOPS complex (homotypic fusion and protein sorting) [26].”
The Beclin 1 network regulates autophagy and apoptosis (2011, positive): “Indeed, UVRAG primarily resides in endocytic compartments such as Rab9-positive late endosomes, as well as partially with Rab5 and Rab7 (Itakura et al.28; Liang et al.42), raising the possibility that it has an additional non-autophagic role.”
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport (2010, background): “In mammals, Rab7, the core class C Vpstethering complex and UVRAG are important for fusion of autophagosomes with lysosomes (Gutierrez et al., 2004; Jäger et al., 2004; Liang et al., 2008).”
TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation (2012, neutral): “…adaptors (Bjørkøy et al., 2005; Thurston et al., 2009; Wild et al., 2011) and the less understood process of the maturation of autophagic organelles into autolysosomes, where the captured material is degraded (Korolchuk et al., 2011; Liang et al., 2008; Matsunaga et al., 2009; Zhong et al., 2009).”
Autophagy-Independent Functions of the Autophagy Machinery (2019, background): “Initially, such an effect, which involves accelerated endosomal maturation, was believed to be unrelated to BECN1 and the VPS34 complex (Liang et al., 2008).”
An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “UVRAG, which can associate with the PtdIns3K complex, can activate the GTPase RAB7, which promotes fusion with lysosomes (59, 86).”