Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

By K. Matsunaga, T. Saitoh, Keisuke Tabata, Hiroko Omori, T. Satoh, Naoki Kurotori, Ikuko Maejima, Kanae Shirahama‐Noda, T. Ichimura, T. Isobe and 3 more. Nature Cell Biology, 2009

1,245 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/1cd8077a3c2e38334f29735162dd1833e1525f9b

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In Cell Biology

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2. Beth Levine
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4. Yongqiang Chen
5. T. Balla
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In Epidemiology

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In Physiology

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Citations in the corpus

• Autophagy, Immunity, and Microbial Adaptations (2009, background): “[PubMed: 15322056] Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura T, Isobe T, et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.”
• Autophagy during viral infection — a double-edged sword (2018, background): “Autophagy is controlled by the sequential activities of three key protein complexes: the serine/threonine protein kinase ulK1 complex (comprising ulK1, FAK family kinase-interacting protein of 200 kDa (FIP200; also known as RB1CC1), ATG13 and ATG101) [146] [147] [148] ; the phosphoinositide 3-kinase”
• Mechanisms of Autophagy Initiation (2017, background): “A cysteine-rich domain near the N-terminus of ATG14L is essential for its starvation-induced translocation to the phagophore initiation sites (88).”
• Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, positive): “containing) interaction leads to autophagy repression (Matsunaga et al., 2009).”
• Principles and Current Strategies for Targeting Autophagy for Cancer Treatment (2011, background): “autophagy onmembranes, whereas PI3K/Beclin1 complexed to Rubicon (22) plays an inhibitory role in membrane trafficking of AV to lysosomes.”
• The regulation of autophagy – unanswered questions (2011, background): “Atg14L (yeast Atg14-like) (Matsunaga et al., 2009; Zhong et al., 2009), activating molecule in beclin-1-regulated autophagy (AMBRA1) (Di Bartolomeo et al.”
• ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase (2013, methodology): “Active GST-ULK1 (1-649) and GST-ULK2 (1-478) from insect cells was purchased from CQuential Solutions (Moraga, CA).”
• The origin of the autophagosomal membrane (2010, background): “The observation that Atg14 localizes to the ER as well as the phagophor”