FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

By S. Pankiv, E. A. Alemu, A. Brech, J. Bruun, T. Lamark, Aud Øvervatn, G. Bjørkøy, T. Johansen. Journal of Cell Biology, 2010

641 citations recorded by the source corpus.

FYCO1 recognition of LC3 on autophagosomes facilitates microtubule-mediated cytosolic transport of this degradative organelle.

Subfields: Cell Biology, Epidemiology

View Paper: https://www.semanticscholar.org/paper/47b31841cfb6b2fedc31d30211e52c4bb8b2dae4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. T. Lamark
2. T. Johansen
3. Jennifer Lippincott-Schwartz
4. R. Yadav
5. H. Chae
6. Ari Helenius
7. Jatta Huotari
8. Hyung-Ryong Kim

In Epidemiology

1. T. Lamark
2. T. Johansen
3. Å. Birgisdottir
4. Jennifer Lippincott-Schwartz
5. R. Yadav
6. H. Chae
7. Ari Helenius
8. Jatta Huotari

Citations in the corpus

• Autophagy pathway: Cellular and molecular mechanisms (2018, background): “It is worth noting that knockdown of FYCO1, an adaptor required for microtubule plus-end-directed transport of autophagic vesicles, also causes clustering of LysoTracker Red-negative autophagic vesicles in the perinuclear region.(42)”
• The LIR motif – crucial for selective autophagy (2013, background): “…(Pankiv et al., 2007; Noda et al., 2008; Sancho et al., 2012), bioinformatics searches (Kraft et al., 2012), proteomics (Behrends et al., 2010; Pankiv et al., 2010), phage display (Mohrlüder et al., 2007b) and yeast two-hybrid assays (Kirkin et al., 2009b; Novak et al., 2010; Wild et al.,…”
• Endosome maturation (2011, background): “Another Rab7 effector, FYCO1, has been reported to have the opposite function and to counteract the effects of RILP by mediating plus-end-directed LE and autophagosome motility (Pankiv et al, 2010).”
• Deacetylation of nuclear LC3 drives autophagy initiation under starvation. (2015, background): “A key regulator of autophagy is LC3 (themicrotubule-associatedprotein 1 light chain 3, a mammalian homolog of yeast Atg8), which controls major steps in the autophagic pathway including the growth of autophagicmembranes, recognitionof autophagic cargoes, and the fusion of autophagosomes with lysosom”
• ER stress: Autophagy induction, inhibition and selection (2015, background): “Similarly, autophagosomal transport and fusion is substantially mediated by the small GTPase RAB7A/RAB7 and its association with FYCO1 (FYVE and coiled-coil domain containing 1) and lysosomal membrane proteins LAMP1/2 accelerate the fusion machinery.(88,89) ATG9, an integral membrane protein, is als”