The Beclin 1 network regulates autophagy and apoptosis

By R. Kang, H. J. Zeh, Michael Lotze, D. Tang. Cell Death and Differentiation, 2011

2,445 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Epidemiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/8620adea9f94bb244852fe1c7338fbc92efaaf66

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Citations in the corpus

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “, ATG5 in cell death, and the PIK3C3/VPS34-containing complexes—including BECN1—in apoptosis, endosomal function and protein trafficking), or may be dispensable for autophagy (see Noncanonical use of autophagy-related proteins).(27,543,573,1141-1144)”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “, ATG5 in cell death, and the VPS34-containing complexes—including BECN1—in apoptosis, endosomal function and protein trafficking).(403,432,703-706) Therefore, the experimental conditions of inhibitor application and their side effects must be carefully considered.”
Mitochondria ROS and mitophagy in acute kidney injury (2022, background): “BCL2 binding to BECN1 is known to inhibit autophagy [107].”
Multiple Functions of BCL-2 Family Proteins (2013, background): “Recent studies indicate that in addition to their apoptotic roles, members of BCL-2 family proteins also regulate autophagy (Levine et al. 2008, 2011; He and Levine 2010; Kang et al. 2011).”
Mitochondria and Mitophagy: The Yin and Yang of Cell Death Control (2012, background): “Initial phagophore formation, or nucleation, requires the assembly of a complex consisting of BECLIN1, vacuolar protein sorting (VPS) 34, and VPS15.”
Autophagy and autophagy-related proteins in cancer (2020, background): “Beclin1 Atg6 Is subunit of the VPS34-PI3K complex; recruits Atg14 or Vps38; interacts with Bcl-2; and lipid binding and membrane deformation [64, 65]”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “It interacts with several cofactors to regulate the class III phosphatidylinositol 3kinase (PI3KC3) and promote formation of Beclin 1-PI3KC3 core complexes, thereby inducing autophagy (39, 40).”
KRAS: feeding pancreatic cancer proliferation (2014, neutral): “These pathways converge on a conserved autophagy machinery including the ULK1 kinase complex, a complex between class III phosphoinositide 3-kinase (PI3KC3) and Beclin-1 [56] which nucleates phagophore formation, and a ubiquitin-like conjugation system (including ATG5) that is necessary for autophag”
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein (2017, background): “As a positive control for an increase in autophagic flux in neurons, we co-expressed Beclin-1, a positive regulator of autophagy that increases autophagy activity when overexpressed (Kang et al., 2011).”
Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, background): “For example, BECN1 and its partners are implicated in the control of apoptosis and other types of RCD in both an autophagydependent and -independent manner, indicating the existence of a BECN1-centric network that orchestrates cell death and stress responses (Kang et al., 2011).”
Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy* (2012, background): “Early autophagic structures contain Beclin1, Atg5, and LC3, whereas only LC3 is retained on the mature autophagosome (35, 36).”