Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop.

By S. Goswami, Erik Sahai, J. Wyckoff, M. Cammer, D. Cox, F. Pixley, E. Stanley, J. Segall, J. Condeelis. Cancer Research, 2005

755 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/320cdc40340fa371a35c5436f9219c1b94fd3399

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. J. Pollard
5. C. Garlanda
6. J. Condeelis
7. C. Lewis
8. C. Porta

In Immunology and Allergy

1. J. Condeelis
2. Erik Sahai
3. Mina J. Bissell
4. M. Swartz
5. P. Steeg
6. Pengfei Lu

In Oncology

1. A. Mantovani
2. A. Sica
3. J. Pollard
4. P. Allavena
5. C. Garlanda
6. J. Condeelis
7. C. Porta
8. Lisa M. Coussens

Citations in the corpus

• Modelling breast cancer: one size does not fit all (2007, positive): “For example, co-cultures have been used to investigate the role of macrophages in promoting breast tumour cell invasion, and these experiments have allowed the delineation of the signalling pathways that mediate crosstalk between breast tumour cells and macrophage”
• Distinct role of macrophages in different tumor microenvironments. (2006, background): “Experiments conducted in vitro and in vivo indicate that each of these cell types exhibit coordinated movement (14, 53).”
• The interaction of anticancer therapies with tumor-associated macrophages (2015, methodology): “Antagonists of the CSF-1R tyrosine kinase have been developed and tested in preclinical models, including acute myeloid leukemia, melanoma mammary carcinoma, and glioblastoma, with promising results (e.g., Goswami et al., 2005; Manthey et al., 2009; DeNardo et al., 2011; Pyonteck et al., 2013).”
• Feedback regulation of EGFR signalling: decision making by early and delayed loops (2011, background): “EGF, in turn, promotes the expression of CSF1 by carcinoma cells, thereby generating a positive-feedback loo”
• Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications (2019, background): “The former cytokine stimulates macrophage’s motility as well as EGF production, which in turn signals to tumor cells and mediates chemotactic migration toward blood vessels [108, 109].”
• Capturing complex 3D tissue physiology in vitro (2006, result): “Recent data support a model in which mammary carcinoma cells secrete colony-stimulating factor-1 ( CSF1 ), which stimulates macrophages to secrete EGF, causing chemotaxis of carcinoma cell”
• The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance (2008, background): “(44) described a paracrine signaling loop between tumor cells and macrophages, in which tumor cells secrete M-CSF.”
• Tumor metastasis: mechanistic insights and clinical challenges (2006, background): “Pathways may be tumor cell autonomous or may involve paracrine loops with cells in the environmen”