Modelling breast cancer: one size does not fit all

By T. Vargo-Gogola, Jeffrey M. Rosen. Nature Reviews. Cancer, 2007

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Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, background): “CD44 is the receptor for HA, one of the extracellular matrix components [28], and as shown in supporting information Figure S1, CD44 expressed in MKN-45 cells actually bound to HA and the different staining patterns of CD44 might originate from different HA localization patterns.”
Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery (2009, background): “Breast cancer cell lines have been used widely to investigate breast cancer pathobiology, and to screen and characterize new therapeutics [6,7].”
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. (2018, neutral): “Although both model systems have contributed tremendously to translational BC research, they also have drawbacks (Vargo-Gogola and Rosen, 2007).”
Choosing the right cell line for breast cancer research (2011, background): “Although questions have been raised over how representative immortalised cell lines are of human breast cancer [15], when used in the right way these remain powerful experimental tools and in many instances the information derived from these has translated into clinical benefi t.”