Distinct role of macrophages in different tumor microenvironments.

By C. Lewis, J. Pollard. Cancer Research, 2006

2,210 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/69c1447787ff8f12ec14df80407134a0e47aaaa1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. Lisa M. Coussens
3. J. Pollard
4. J. Joyce
5. D. Hanahan
6. Zena Werb
7. Subhra K. Biswas
8. Binzhi Qian

In Molecular Biology

1. Zena Werb
2. Lisa M. Coussens
3. J. Joyce
4. M. Egeblad
5. A. Mantovani
6. E. Nakasone
7. J. Pollard
8. D. Hanahan

Citations in the corpus

• M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide (2015, background): “Many studies have shown on one hand an inverse correlation between macrophage abundance in a tumor and patient prognosis and survival, and on the other hand a positive correlation with resistance to chemotherapy [11, 27–29].”
• Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. (2010, background): “It has been predicted that TAMs in different tumor regions might have specialized functions (4).”
• Classifying cancers based on T cell infiltration and PD-L1 (2015, neutral): “When it has been characterized, it appears that the nega48 tively impacting macrophages are of the M2 phenotype (7).”
• The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer (2016, background): “Consistent with the known role of phagocytic lineage cells, such as TAMs, in the angiogenic process (95), there is a positive correlation between microvessel density, levels of infiltrating TAMs in tumor vessel areas, and poor prognosis (237, 238).”
• Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy (2020, background): “Tumor-associated macrophages are the most frequent immune cells found in the TME (Lewis and Pollard, 2006).”
• Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis. (2018, background): “Tumor metastasis is closely correlated with tumor microenvironment in which hypoxia and inflammatory cells infiltration especially macrophages are two important factors (6, 7).”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, neutral): “VEGF, PDGF, bFGF, CXCL8) [1,66-76].”
• Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, positive): “For example, macrophages are the primary source of EGF in the developing mammary gland and in mouse models of breast cancer (Leek et al., 2000; Lewis and Pollard, 2006).”
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, positive): “Changes in the stromal compartment that occur with increasing tumor stage include alteration of the function of vascular cells and tumorassociated fibroblasts, and increasing influx of inflammatory cells (Bissell and Radisky, 2001; Coussens and Werb, 2002; Lewis and Pollard, 2006).”
• Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment (2014, background): “TAMs are believed to directly and indirectly affect the metastatic process of tumor cells by modulating the tumor microenvironment [77,78].”
• Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “Tumor-associated myeloid cells are very heterogeneous, behaving differently and likely having different functions at the invading edge, along blood vessels and in hypoxic regions of tumors (Figure 3A; Movie S1) (Egeblad et al., 2008; Lewis and Pollard, 2006; Wyckoff et al., 2007).”