Feedback regulation of EGFR signalling: decision making by early and delayed loops
By R. Avraham, Y. Yarden. Nature reviews. Molecular cell biology, 2011
670 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/29901fda3c8a71b5eaefc870a70e9ebe310419e9
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Carlos L. Arteaga
- J. Engelman
- Jonathan M Cooper
- Jens Timmer
- Birgit Schoeberl
- Igor Ulitsky
- Y. Yarden
- F. Giancotti
In Oncology
- Carlos L. Arteaga
- J. Engelman
- Birgit Schoeberl
- Jonathan M Cooper
- Y. Yarden
- F. Giancotti
- M. Lacouture
Citations in the corpus
- Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “In normal cells, flux through the major signaling pathways jointly activated by integrins and RTKs is limited by strong negative feedback mechanisms, which adjust the amplitude and frequency of signaling to the physiological needs of tissue development and repair, and act as a barrier to tumor devel”
- Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor (2015, background): “Correspondingly, EGF family growth factors induce wave-like bursts of transcription of distinct RNA molecules, starting with a group of immediate early genes (IEGs) and culminating in a large group of fate-determining mRNAs (4).”
- ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics (2014, background): “…cascades are determined by the expression of positive and negative regulators, the specific composition of activating ligand(s), receptor dimer constituents, and the array of proteins that associate with the tyrosine phosphorylated C-terminal domain of the ERBB receptors (Avraham and Yarden, 2011).”
- Predicting ligand-dependent tumors from multi-dimensional signaling features (2017, background): “After internalization, the receptor dimers can get either dephosphorylated and recycled to the cell surface or they get degraded in the lysosomes.(34,35) Downstream of the receptor, all homo- and heterodimers except the ErbB3-homodimer, which cannot transphosphorylate due to its lack of intrinsic ki”