Capturing complex 3D tissue physiology in vitro

By L. Griffith, M. Swartz. Nature reviews. Molecular cell biology, 2006

2,333 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/1c7f88d8161cb1117fb72204fc3a2fbc0cd96afb

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Citations in the corpus

Three-Dimensional Cell Culture: A Breakthrough in Vivo (2015, background): “aggregates require the careful exchange of nutrients and gases in addition to spatial control, and problems with cell death arise when aggregate thickness of 1–2 mm arise through a lack of mass transfer, principally through a limited exchange of nutrients and waste metabolites [7,16].”
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “Indeed, the coupling between mechanical forces and solute transport might be another important means by which mechanical signals can be transduced into cell signaling in three dimensions (Griffith and Swartz, 2006).”
Three-dimensional bioprinting of thick vascularized tissues (2016, background): “In addition to providing transport of nutrients, oxygen, and waste materials, the perfused vasculature is used to deliver specific differentiation factors to the tissue in a more uniform manner than bulk delivery methods, in which cells at the core of the tissue are starved of factors (25).”
Physical approaches to biomaterial design (2009, background): “Such extraordinary emphasis on chemistry is consistent with the notion that molecular recognition forms the basis of many biological function”
Rapid casting of patterned vascular networks for perfusable engineered 3D tissues (2012, background): “Yet the lack of a general approach to rapidly construct such networks remains a major challenge for 3D tissue culture [2–4].”
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “Such a model would include cell-to-cell and cell-to-ECM interactions, tissue-specific stiffness, oxygen, nutrient and metabolic waste gradients, and a combination of tissue-specific scaffolding cells (Griffith and Swartz, 2006).”
The ToxCast program for prioritizing toxicity testing of environmental chemicals. (2007, background): “Such tissue engineering raises new possibilities for the study of complex toxicological processes in vitro (Griffith and Swartz, 2006), and the convergence of HTS and toxicogenomic data with systems biology is creating opportunities for developing bioengineered and computational models that more…”
Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. (2010, background): “Despite hallmark outcomes obtained using current gold standard 3D models, there is a need for 3D systems that are more reliable, reproducible and possess controllable characteristics [2,4,9,25].”
Harnessing Traction-Mediated Manipulation of the Cell-Matrix Interface to Control Stem Cell Fate (2010, background): “Moreover, as most work linking substrate mechanics to cell fate has been done in 2D model systems, the extent to which ECM rigidity affects cell phenotype in more physiologically relevant three-dimensional (3D) culture systems is also uncertai”
Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration (2007, background): “The second major challenge is how to fabricate these polymers into scaffolds that have defined shapes and a complex porous internal architecture that can direct tissue growth (Griffith & Schwartz 2006).”
Vascularization Strategies for Tissue Engineering (2009, neutral): “Thus, accurate modeling of engineered tissues in vitro should consider these issues as well.(122,123) In considering oxygen transport, the most basic modeling components to be described are fluid flow, oxygen diffusion, and oxygen consumption.”
2D and 3D cell cultures – a comparison of different types of cancer cell cultures (2016, methodology): “In this context, the use of 3D systems could avoid over- or underestimation of a specific drug in case of drug sensitivity and resistance, as well as its dosage [35, 36].”