Tumor metastasis: mechanistic insights and clinical challenges

By P. Steeg. Nature Medicine, 2006

2,176 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/93ee2a84316d4883084f8fe51a5f682610db33da

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Citations in the corpus

Metastasis: from dissemination to organ-specific colonization (2009, background): “jpg" NDATA ITEM> ]> Tumour progression towards metastasis is often depicted as a multistage process in which malignant cells spread from the tumour of origin to colonize distant organ”
In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform (2016, background): “In the series of steps that comprise the metastatic process, cancer cells migrate or flow through vastly different microenvironments, including stroma, blood vessel endothelium, the vascular system, and the tissue at a secondary site (Chambers et al., 2002; Fidler, 2003; Steeg, 2006).”
Revisiting the hallmarks of cancer. (2017, neutral): “Metastatic disease is responsible for over 90% of cancer-related deaths [101], and involves a series of events, the “invasionmetastasis cascade”.”
The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, neutral): “jpg"/> In the series of steps that comprise the metastatic process, cancer cells migrate or flow through vastly different microenvironments, including the stroma, the blood vessel endothelium, the vascular system and the tissue at a secondary sit”
Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “This explains why > 90% of mortality from cancer is attributable to metastases, not the primary tumors from which these malignant lesions arise (Gupta and Massagué, 2006; Steeg, 2006).”
Isolation of rare circulating tumour cells in cancer patients by microchip technology (2007, background): “Two essential parameters that determine the efficiency of cell capture on the CTC-chip are: (1) flow velocity, because it influences the duration of cell–micropost contact; and (2) shear force, which must be sufficiently low to ensure maximum cell–micropost attachment.”
Genetic determinants of cancer metastasis (2007, background): “Recent reviews have comprehensively analysed the biological traits and steps of cancer metastasi”
Real-time imaging reveals the single steps of brain metastasis formation (2010, background): “2072" language="eng" relation="no"> Metastasis formation is responsible for most cancer death”
Opportunities and Challenges for use of Tumor Spheroids as Models to Test Drug Delivery and Efficacy (2012, neutral): “Response of cells to drug delivery systems is dependent on these interactions; indeed, drugs effective against specific cells in one site may not work against the “same” cells in a different organ/tissue [76, 77].”
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche (2009, background): “There are few effective treatment options for patients with metastatic disease (Steeg, 2006), and over 90% of cancer-related deaths can be attributed to tumor metastases (Gupta and Massague, 2006).”