An Extensive Class of Small RNAs in Caenorhabditis elegans

By Rosalind C. Lee, V. Ambros. Science, 2001

3,131 citations recorded by the source corpus.

Subfields: Aging, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3142f9c54220f78c8500c6149df1667332ea9d6c

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Citations in the corpus

Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes. (2004, background): “Other miRNAs are thought to interact with target mRNAs by limited complementarity and suppressed translation as well (5, 8 ).”
Small silencing RNAs: an expanding universe (2009, neutral): “In 2001, tens of miRNAs were identified in humans, flies and worms by small RNA cloning and sequencing, thereby establishing miRNAs as a new class of small silencing RNA”
miR-155 gene: a typical multifunctional microRNA. (2009, neutral): “thought [69-71].”
Inferring Noncoding RNA Families and Classes by Means of Genome-Scale Structure-Based Clustering (2007, background): “Starting with the discovery of microRNAs [1–3] and the advent of genome-wide transcriptomics [4–6], it has become obvious that RNA plays a large variety of important, often regulatory, roles in living organisms that extend far beyond being a mere intermediate one in protein biosynthesis.”
Non–coding RNA genes and the modern RNA world (2001, background): “; specially designed cDNA cloning screens for a new regulatory RNA gene family of tiny RNAs called microRNAs (miRNAs”
The Microprocessor complex mediates the genesis of microRNAs (2004, background): “It was recently suggested that most miRNA genes originate from independent transcription unit”
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. (2010, background): “MicroRNAs (miRNA) are ∼22-nucleotide RNAs that negatively regulate gene expression in eukaryotes (1).”
A biochemical framework for RNA silencing in plants. (2003, background): “GENES & DEVELOPMENT 17:49–63 © 2003 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/03 $5.00; www.genesdev.org 49 Dicer homolog) in plants also generate microRNAs (miRNAs), 20–24-nt, single-stranded noncoding RNAs thought to regulate endogenous mRNA expression (Lee et al. 1993; Reinhart et al.”
Human embryonic stem cells express a unique set of microRNAs. (2004, background): “…so far (Aravin et al., 2003; Dostie et al., 2003; Grad et al., 2003; Lagos-Quintana et al., 2001, 2002, 2003; Lai et al., 2003; Lau et al., 2001; Lee and Ambros, 2001; Lee et al., 1993; Lim et al., 2003b; Llave et al., 2002a; Mourelatos et al., 2002; Park et al., 2002; Reinhart et al., 2000,…”
miRNAs in human cancer (2010, background): “Homologues of let-7 or lin-4 /miR-125 were thereafter shown to have temporal expression in other organisms, including mammals, and to regulate mammalian development [5–8].”
Computational and experimental identification of C. elegans microRNAs. (2003, methodology): “In our third algorithm, we searched for possible C. elegans homologs of 164 miRNAs cloned from C. elegans, D. melanogaster, M. musculus, and H. sapiens (Figure 1; Lee and Ambros, 2001; Lau et al., 2001; Lagos-Quintana et al., 2001).”
A microRNA array reveals extensive regulation of microRNAs during brain development. (2003, background): “Many miRNAs, often with highly conserved sequences, are present in the genomes of Caenorhabditis elegans, Drosophila , mice, and humans (Lagos-Quintana et al. 2001, 2002; Lau et al. 2001; Lee and Ambros 2001; Mourelatos et al. 2002; Dostie et al. 2003).”
The rise of regulatory RNA (2014, background): “…remained interesting idiosyncrasies until the discovery of RNAi (see below), which led to the targeted cloning after size selection of many more 51–53 and the demonstration that these ‘microRNAs’ (miRNAs) act, at least in part, by imperfect base pairing with (usually) the 3 ′ UTRs of target mRNAs…”