The rise of regulatory RNA

By Kevin V. Morris, John S. Mattick. Nature reviews genetics, 2014

1,273 citations recorded by the source corpus.

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d2bb9986f6df1c6b9dd69318e675fda5f7d76333

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Citations in the corpus

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them (2017, background): “N(6)‐methyladenosine‐dependent RNA structural switches regulate RNA‐protein interactions.”
Comprehensive Genomic Characterization of Long Non-Coding RNAs across Human Cancers (2015, background): “…from enhancer regions or their neighboring loci (Batista and Chang, 2013; Guttman and Rinn, 2012; Karreth and Pandolfi, 2013; Lee, 2012; Mattick and Rinn, 2015; Mercer et al., 2009; Morris and Mattick, 2014; Ørom and Shiekhattar, 2013; Prensner and Chinnaiyan, 2011; Ulitsky and Bartel, 2013).”
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016, positive): “On the other hand, long non-coding RNAs (lncRNAs) and pseudogenes can act as regulators of transcription (Morris and Mattick, 2014), compete with endogenous RNAs, or act as miRNA sponges to post-transcriptionally regulate the levels and dynamics of protein-coding transcripts (Tay et al., 2014).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “This length threshold is a simple but convenient biophysical cut-off that separates lncRNAs from smaller ncRNA species such as miRNAs, siRNAs, and others (184, 197).”
Circular RNAs: analysis, expression and potential functions (2016, background): “KEY WORDS: CircRNA, Splicing, Regulation, Development, Non-coding RNA Introduction The past decades have seen an ever-growing list of diverse noncoding RNA species with functional capacity expressed in eukaryotic cells (Morris and Mattick, 2014).”
Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation (2015, background): “This class of genes is generally defined as being transcripts > 200 nt in length that lack strong protein-coding potential (23). lncRNA RefSeq records are generated by curation and through the eukaryotic genome annotation pipeline for lncRNA genes.”
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer (2017, background): “In the nucleus, they can modify epigenetic markers by activating or suppressing chromatin modification proteins such as DNMT3A, whereas in the cytoplasm, they can act as a miRNA decoy, translation regulators or splicing regulators [84].”