The Microprocessor complex mediates the genesis of microRNAs

By Richard I. Gregory, Kai-ping Yan, G. Amuthan, T. Chendrimada, Behzad Doratotaj, Neil Cooch, R. Shiekhattar. Nature, 2004

2,871 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/8b7071eb71b264b7374cbccc79c521eaa5c0786c

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Citations in the corpus

Processing of primary microRNAs by the Microprocessor complex (2004, background): “A parallel study shows an association between DGCR8 and human Drosha, and presents biochemical and genetic evidence that these proteins cooperate to determine the specificity of Drosha cleavag”
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation (2005, neutral): “Anti-dimethyl K4H3 (12-460), anti-monomethyl K4H3”
A human snoRNA with microRNA-like functions. (2008, background): “(C) FH-DGCR8 or untreated cells were immunoprecipitated using anti-FLAG antibodies.”
Processing of intronic microRNAs (2007, background): “Drosha functions as a complex called ‘Microprocessor’ that also contains a double-stranded RNAbinding protein, DGCR8 (also known as Pasha in flies and nematodes) (Denli et al, 2004; Gregory et al, 2004; Han et al, 2004; Landthaler et al, 2004).”
Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. (2005, methodology): “Analysis of FLAG-Dicer by Superose 6 and Superdex 200 gel filtration was as described previously (Gregory et al., 2004).”
Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients (2008, background): “The pri-miRNA is then cleaved by Drosha and its partner protein DGCR8 into an approximately 70-nucleotide precursor miRNA (pre-miRNA) molecule [9-13].”
Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs[OPEN] (2013, background): “, 2004), microprocessor interactions include the spliceosome-associated components p68 and p72 (Gregory et al., 2004), FUS (Shiohama et al.”
Current prospects for RNA interference-based therapies (2011, background): “Primary microRNAs (pri-miRNAs) are transcribed by RNA polymerases [156] [157] [158] and are trimmed by the microprocessor complex (comprising Drosha and microprocessor complex subunit DCGR8) into ~70 nucleotide precursors, called pre-miRNAs 67, 159, 160 (left side of the figure).”
Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein (2005, background): “double-stranded RNA-binding domain (dsRBD) protein partner, known as Pasha in Drosophila melanogaster [10] and DGCR8 in humans [11–13].”
MicroRNA biogenesis and cancer. (2005, background): “www.aacrjournals.org 3511 Cancer Res 2005; 65: ( 9 ).”
microRNAs as oncogenes and tumor suppressors. (2007, background): “Then, pri-miRNAs form specific hairpin-shaped stem–loop secondary structures and enter a microprocessor complex (500–650 kDa) consisting of a Drosha (a RNase III endonuclease) and an essential cofactor DGCR8/Pasha (protein containing two double-stranded RNA binding domains) (Denli et al., 2004; Greg”
Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration (2011, background): “Furthermore, knockdown of TDP43 alters the level of several miRNA”
Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms (2011, neutral): “Lin28A localizedmostly to the cytoplasm and therefore showed no overlapwith the nuclear DGCR8.”