Smoldering and polarized inflammation in the initiation and promotion of malignant disease.

By F. Balkwill, K. Charles, A. Mantovani. Cancer Cell, 2005

1,844 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/2f16874fd78cd3c46a441c28f200e500738af840

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. J. Pollard
3. M. Karin
4. D. Hanahan
5. A. Sica
6. P. Allavena
7. Lisa M. Coussens
8. Guido Kroemer

In Oncology

1. M. Karin
2. J. Pollard
3. A. Mantovani
4. D. Hanahan
5. Lisa M. Coussens
6. R. Weinberg
7. P. Allavena
8. A. Sica

In Psychiatry and Mental health

1. J. Pollard
2. M. Karin
3. Lisa M. Coussens
4. D. Hanahan
5. P. Allavena
6. A. Sica
7. J. Condeelis
8. A. Mantovani

Citations in the corpus

• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “inflammation is typically smoldering [37], TAM usually have”
• Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. (2006, background): “The inflammatory response to stress-mediated, oncogene-activated necrosis in tumors, by analogy to a wound healing response, may stimulate angiogenesis and tumor cell proliferation (Balkwill et al., 2005; Balkwill and Coussens, 2004; Vakkila and Lotze, 2004; Zeh and Lotze, 2005).”
• Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors (2009, background): “has been considered a tumor-promoting condition, arguing in favor of IL-1β inhibition for tumor prevention or therap”
• Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity (2015, background): “Mediators secreted by these cells that directly or indirectly promote cancer cell growth include cytokines, chemokines, and growth factors, such as VEGF-A, CSFs, IL-1, IL-6, IL-8, or CXCL1 (Balkwill et al., 2005; Coussens et al., 2013).”
• Obesity and cancer risk: Emerging biological mechanisms and perspectives. (2019, background): “Increased FFAs levels are found in obese individuals and are associated with ER stress in adipocytes [155].”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “In most studies accumulation of TAM has been associated with the angiogenic switch and poor prognosis [3,4,60,61].”
• A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth (2009, background): “These tumor-associated macrophages have been described as trophic macrophages [46] or M2 [47] since they have a phenotype that suggests developmental, tissue remodeling as well as immune-regulatory functions that suppress cytotoxic immune responses [48,49,50].”
• Paradoxical roles of the immune system during cancer development (2006, background): “Moreover, population-based studies reveal that individuals who are prone to chronic inflammatory diseases have an increased risk of cancer developmen”
• Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. (2007, background): “as 15% of the world’s malignant cancers (32).”
• Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “In the 1970s, it was found that TAMs, as the predominant leukocyte, play a key role in tumor growth [26].”
• Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease (2009, background): “Moreover, excessively and chronically produced proinflammatory mediators are thought to contribute to tumor promotion and progression [121, 126].”
• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “Inflammation is a biological process that is initiated upon injury to remove harmful stimuli and to initiate a healing process (6).”
• A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007, positive): “Recent data from mouse models of human cancer have established that inflammation, which orchestrates the tumor microenvironment, is a critical component of both tumor promotion and tumor progression (8–10).”
• Photodynamic therapy and anti-tumour immunity (2006, background): “The tumour environment is more aptly described as a state of chronic inflammation, as opposed to a state of acute inflammatio”