Photodynamic therapy and anti-tumour immunity

By A. Castano, Pawel Mróz, Michael R Hamblin. Nature Reviews. Cancer, 2006

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How researchers see this paper

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Cell Death Pathways in Photodynamic Therapy of Cancer (2011, background): “Additionally, PDT leads to activation of tumor directed, systemic immune responses [8-10].”
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death (2012, positive): “PDT can induce oxidative stress at certain subcellular sites by activating organelle-associated photosensitizers (Castano et al , 2006; Buytaert et al , 2007).”
Photodynamic therapy of cancer. Basic principles and applications (2008, background): “These hypoxic vascular effects are associated with the inhibition or delay of tumour growth [1, 4, 36, 37].”
The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology (2012, methodology): “The working model is sketched in figure 25, following Castano et al [127], in which PDT is shown inducing both tumour apoptosis and necrosis, generating acute local inflammation and attracting dendritic cells (DCs) to phagocytose these necrotic cells.”
Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions (2017, background): “Multiple studies with different PSs showed upregulation of transcription factors after PDT, under which NFκB and AP1 (reviewed by [33]).”