Paradoxical roles of the immune system during cancer development

By K. E. Visser, A. Eichten, Lisa M. Coussens. Nature Reviews. Cancer, 2006

2,336 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1113a357c21ac3e504892b1201484708c7b563a9

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Citations in the corpus

Immunity, Inflammation, and Cancer (2010, neutral): “B lymphocytes and mast cells are also important contributors to immune-mediated tumor growth (Ammirante et al., 2010;de Visser et al., 2006;Soucek et al., 2007) and conventional macrophages and dendritic cells are important for antigen presentation and T cell activation during anti-tumor immunity…”
A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007, neutral): “…involved in tumor initiation (the process by which normal cells are genetically altered so that they become malignant), promotion (the process by which small clusters of malignant cells are stimulated to grow), and progression (the process by which the growing tumor becomes more aggressive) (2–7).”
Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics (2007, background): “On the other hand, attenuation of innate inflammation following GSK3 inhibition could explain the absence of an effect of lithium alone on tumor formation, since in the absence of infiltration of immune cells, components of tumor development, such as increased cell survival, tissue remodeling, angio”
Microenvironmental regulation of metastasis (2009, background): “Even within individual cell types, there are opposing functions; for example, CD4 + T cells, macrophages, and natural killer (NK) T cells have either tumour-suppressive or tumour-promoting properties depending on the tissue context and cellular stimul”
The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “jpg" NDATA ITEM> ]> Various epidemiological, clinical and experimental studies have not only demonstrated a link between chronic inflammation and cancer onset but also shown that inflammatory mediators such as myeloid cells significantly contribute to tumour progressio”
Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy (2016, methodology): “When the primary tumours reached B100mm3, mice were randomly divided into seven groups (n1⁄4 6): (1) PBS with irradiation, NCP@pyrolipid (2) without or (3) with irradiation, NCP@pyrolipid plus anti-PD-L1 (4) without or (5) with irradiation, (6) porphysome with irradiation plus anti-PD-L1 and (7) oxa”
Macrophage activation by endogenous danger signals (2008, background): “While it is clear that in some experimental systems antibodies to tumour-associated antigens can be protective, there are also a number of instances in which antibody depletion actually leads to reduced tumour growth [144,145].”
Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, background): “Autologous immune cells are an important element of the tumor microenvironment as they can either promote or impair tumor growth (de Visser et al., 2006).”
CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages (2009, background): “…of neoplastic tissue by leukocytes, i.e., chronic inflammation , promotes development and/or progression of various epithelial tumors (de Visser et al., 2006; Mantovani et al., 2008); however, the organ-specific cellular and molecular programs that favor protumor, as opposed to…”