Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.

By K. Degenhardt, Robin Mathew, Brian Beaudoin, Kevin Bray, Diana Anderson, Guanghua Chen, Chandreyee Mukherjee, Yufang Shi, C. Gélinas, Yongjun Fan and 3 more. Cancer Cell, 2006

2,081 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b90056cdefb2459a759a40e8bbc177f529027f2c

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Citations in the corpus

p62 links autophagy and Nrf2 signaling. (2015, background): “On the other hand, increased autophagic activity allows cancer cells to cope with high metabolic and proteotoxic stress, which is essential to their survival [15].”
Potential therapeutic applications of autophagy (2007, background): “A major question, however, is: what role does autophagy play during PtdIns-3-kinase therapy? Recent studies have suggested that cells with genetic inactivation of the type I programmed cell-death pathway can survive growth-factor and nutrient limitation owing to autophagy signalling, which suggests ”
Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment (2009, positive): “Several studies point to a cancer-promoting role for autophagy: cancer cells use autophagy as a survival pathway to sustain viability during periods of nutrient limitation, growth-factor deprivation, and metabolic stress (13, 25, 70).”
Targeting autophagy in cancer (2018, background): “Early studies demonstrated that loss of autophagy genes promotes tumor inflammation.(83,88) In this context, conflicting reports on the role of autophagy in tumor immunity continue to cloud the picture of whether or not antiautophagy therapy will promote or suppress tumor immunity.”
The Roles of Autophagy in Cancer (2018, background): “Suppression of autophagy by deletion of Beclin 1 enhances cell death [73,74].”
Autophagy mediates the mitotic senescence transition. (2009, background): “These effector mechanisms include epigenetic regulation (Narita et al. 2006; Adams 2007), the DNA damage response (Bartkova et al. 2006; Di Micco et al. 2006; Mallette et al. 2007), and the senescence-associated secretion phenotype (Kortlever et al. 2006; Acosta et al. 2008; Coppé et al. 2008;…”
Autophagy, Metabolism, and Cancer (2015, positive): “Optimal drug combinations are only beginning to emerge, with proteasome and BRAF inhibitor combinations with autophagy inactivation showing promise (35, 51, 55, 61, 66).”
Regulation of autophagy by cytoplasmic p53 (2008, methodology): “Beclin 1 (–) DiOC6(3) low/PI+ DiOC6(3) low/PI–”
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells (2008, methodology): “The siRNA specific for human beclin-1 was purchased from Dharmacon (Lafayette, CO, USA) and the sequences used were same as those by Degenhardt et al.29 The siRNA specific for atg-5 was purchased from Sigma Proligo (The Woodlands, TX, USA) and the sequences used were same as those by Boya et al.38 a”
The Role of Autophagy in Cancer: Therapeutic Implications (2011, background): “Evidence indicates that the predominant role of autophagy in cancer cells is to confer stress tolerance, which serves to maintain tumor cell survival (1).”
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “In addition to effects on tumor cells, autophagy defects can indirectly promote tumorigenesis through inflammation.(67) The Thr300Ala mutation in ATG16L1 may lead to chronic inflammatory Crohn’s disease, thereby predisposing patients to colorectal cancer.”
Oxidative stress and autophagy: the clash between damage and metabolic needs (2014, background): “damaged mitochondria (mitophagy) and toxic aggregates, autophagy eliminates putative sources of ROS, reduces their levels and, if only indirectly, decreases DNA damage accumulation.(114,121,122) This assumption provides a general explanation of the important role of autophagy in maintaining genomic ”
Recent insights into the function of autophagy in cancer (2016, background): “Evidence that autophagy promotes growth of advanced cancer A first indication that autophagy may promote cancer came from the observations that autophagy is up-regulated in hypoxic tumor regions, suppresses tumor-induced inflammation, and promotes tumor cell survival (Degenhardt et al. 2006).”