Signalling, cell cycle and pluripotency in embryonic stem cells.

By T. Burdon, Austin G Smith, P. Savatier. Trends in Cell Biology, 2002

713 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/29643e5e5715f05ea5e14b9dab01dde09d99c978

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Citations in the corpus

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. (2005, background): “DCR / cells also showed no evidence of aneuploidy or genomic instability, suggesting that ES cells use different mechanisms for maintaining genomic stability than differentiated cells (Burdon et al. 2002).”
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment (2007, background): “Presence of the self-renewal cytokine LIF, which activates Erk in addition to Stat3 (Burdon et al., 2002; Burdon et al., 1999), only partially restored pErk levels in the null cells and did not further augment pErk in the heterozygous cells.”
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (2003, background): “…showed that mobility of consensus oligonucleo- Prior to this study, LIF/gp130/Stat3 was the only known biochemical pathway that could maintain self-renewaltides was retarded by extracts of F9 embryonic carcinoma cells (Figure 7B) and RF8 ES cells (data not of mouse ES cells (Burdon et al., 2002).”
Distinct factors control histone variant H3.3 localization at specific genomic regions (2010, background): “We speculate that Hira / ESCs may be rescued by the replicationcoupled deposition of histones during the frequent S phases of rapidly dividing ESCs (Burdon et al., 2002).”
Adaptation to culture of human embryonic stem cells and oncogenesis in vivo (2007, background): “In MESCs, GRB2 has been implicated in ERK signaling that encourages differentiatio”
Capture of authentic embryonic stem cells from rat blastocysts. (2008, positive): “Propidium iodide staining revealed that more than 50% of cells are in S phase, a cell-cycle profile shared with mouse ES cells (Figure 5C) and distinct from most somatic cells that tend to reside in G1 (Burdon et al., 2002).”
Cell-cycle control and cortical development (2007, background): “It is tempting to speculate that shortening of the G1 phase might shield stem cells from signals that induce differentiatio”
Mechanisms of stem cell self-renewal. (2009, background): “Mouse ES cells have a very short G1 phase of the cell cycle, marked by little or no hypophosphorylated Rb (Burdon et al. 2002, Stead et al. 2002).”
How is pluripotency determined and maintained? (2007, background): “During self-renewal, most ES cells are in the S phase of the cell cycle, with only a few in G1 (Burdon et al., 2002).”
Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression (2003, background): “The G(2) DNA damage checkpoint targets both Wee1 and Cdc25.”
Embryonic Stem Cell Specific MicroRNAs Regulate the G1/S Transition and Promote Rapid Proliferation (2008, background): “The rapid proliferation of ES cells is thought to be due to their unique cell cycle structure, especially their shortened G1 phas”
Cdks, cyclins and CKIs: roles beyond cell cycle regulation (2013, background): “It is well-established that pluripotent embryonic stem cells (ESCs) possess a distinctive mode of cell cycle regulation characterized by rapidly alternating rounds of S and M phases that are interspersed by short gap phases (Becker et al., 2006; Burdon et al., 2002; Singh and Dalton, 2009).”