Adaptation to culture of human embryonic stem cells and oncogenesis in vivo

By D. Baker, Neil J. Harrison, E. Maltby, Kath Smith, H. Moore, P. Shaw, P. Heath, H. Holden, P. Andrews. Nature Biotechnology, 2007

675 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. (2010, background): “…were in chromosomes 12 and 17 (three cell lines each), coinciding with their previously suggested role in embryonic tumors and ESC adaptation (Baker et al., 2007; Reuter, 2005 HiPSCs are similar to HESCs in many respects, even though some differences have been observed between the two cell…”
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver (2015, positive): “ES cell cultures routinely show abnormal karyotypes (Baker et al., 2007), and iPS cells can harbor considerable numbers of somatic CNVs (Hussein et al.”
Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ES and iPS Cells during Reprogramming and Time in Culture (2011, positive): “Human embryonic stem cell (hESC) lines have been shown to become aneuploid in culture (Baker et al., 2007; Draper et al., 2004; Imreh et al., 2006; Maitra et al., 2005; Mitalipova et al., 2005), and the most frequent changes, trisomies of chromosomes 12 and 17, are also characteristic of malignant…”
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative (2007, background): “One observation that might impinge on such potential variability is the evident potential for culture adaptation and genetic instability of hES cell lines during prolonged passag”