The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.

By Kaoru Mitsui, Yoshimi Tokuzawa, H. Itoh, K. Segawa, Mirei Murakami, Kazutoshi Takahashi, Masayoshi Maruyama, M. Maeda, S. Yamanaka. Cell, 2003

3,375 citations recorded by the source corpus.

Subfields: Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/feb24329326b51a262be91ad45b8208d6975d58a

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Citations in the corpus

Naive and primed pluripotent states. (2009, background): “As gastrulation proceeds and the epiblast differentiates, both factors are extinguished in all somatic lineages (Chambers et al., 2003; Mitsui et al., 2003).”
Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts (2014, background): “10A), consistent with these genes’ roles as master regulators in undifferentiated ESCs regulating the maintenance of developmental potency (Niwa et al. 2000; Mitsui et al. 2003).”
Capture of authentic embryonic stem cells from rat blastocysts. (2008, positive): “A second critical marker of pluripotent status, Nanog (Chambers et al., 2003; Mitsui et al., 2003), which is downregulated in similar fashion to Oct4 in conventional culture, was similarly maintained in serum-free medium supplemented with 3i, although with a more heterogeneous expression than Oct4.”
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. (2004, background): “role in generation of the intraembryonic lineage (10, 11).”
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse (2009, background): “Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.”
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells (2007, background): “Null mutations of each of these genes results in early embryonic lethality due to the inability to maintain pluripotent cell”
Mechanisms of stem cell self-renewal. (2009, background): “The homeodomain protein Nanog is also required for the maintenance of pluripotency in the inner cell mass in vivo (Mitsui et al. 2003).”
Roadmap to embryo implantation: clues from mouse models (2006, background): “The consensus is that, while both NANOG and OCT4 are required for ICM specification, they suppress the formation of extraembryonic lineages; OCT4 represses trophoblast and NANOG parietal–visceral endoderm formatio”
Strategies and new developments in the generation of patient-specific pluripotent stem cells. (2007, background): “The inactivation of STAT3 in mouse ES cells markedly decreases KLF4 expression, and forced expression of KLF4 enables LIF-independent self-renewal (Table 1; Y. Tokuzawa, M. Nakagawa, and S.Y., unpublished data).”
An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “Nanog promotes ES cell self-renewal and alleviates the requirement for Leukemia Inhibitory Factor (LIF) (Chambers et al., 2003; Mitsui et al., 2003).”
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. (2003, background): “Cell, Vol. 113, 643–655, May 30, 2003, Copyright 2003 by Cell Press”