FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment

By T. Kunath, M. Saba-El-Leil, Marwa Almousailleakh, Jason Wray, S. Meloche, Austin G Smith. Development, 2007

837 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e99c764f741a5df95d047db47dfc9a0a08fd02a5

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In Molecular Biology

1. Jennifer Nichols
2. Austin G Smith
3. José C. R. Silva
4. M. Roode
5. G. Guo
6. Janet Rossant
7. R. Nusse
8. Jian Yang

Citations in the corpus

• Klf4 reverts developmentally programmed restriction of ground state pluripotency (2009, background): “They are driven into differentiation by FGF/Erk signalling (Kunath et al., 2007; Stavridis et al., 2007).”
• The Transcriptional and Epigenomic Foundations of Ground State Pluripotency (2012, background): “The inhibitors shield pluripotent cells from differentiation triggers: fibroblast growth factor-4 stimulation of the Mek-Erk pathway and endogenous repressor activity of Tcf3 (Kunath et al., 2007; Wray et al., 2011).”
• Wnt signaling and stem cell control (2008, background): “In culture, mouse ES cell differentiation is triggered by the spontaneous expression of fibroblast growth factor 4 (FGF4) and the subsequent activation of the mitogen-activated protein kinase/extra-cellular signal-related kinase (MAPK/ERK) signaling pathway (Kunath et al. 2007; Stavridis et al. 2007”
• FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst (2010, background): “5 blastocyst is not a homogeneous population but rather a mixed population of PE and EPI progenitors (Chazaud et al., 2006; Kurimoto et al., 2006; Plusa et al., 2008).”
• Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo (2009, background): “Authentic ES cells are characterised by the unusual capacity to proliferate in the presence of selective inhibition of the Mek/Erk1/2 signalling pathway (Buehr et al., 2008; Burdon et al., 1999; Chen et al., 2006; Kunath et al., 2007; Li et al., 2008; Ying et al., 2008).”
• Naive and primed pluripotent states. (2009, background): “Genetic and biochemical studies have indicated that stimulation of the Erk pathway by Fgf4 and other extrinsic stimuli is a signal that primes ESCs for lineage specification (Burdon et al., 1999; Kunath et al., 2007; Stavridis et al., 2007).”
• Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. (2010, background): “factor (LIF)-BMP-2 mediated differentiation into cardiomyocytes (331) and other lineage commitment (215, 381).”