Capture of authentic embryonic stem cells from rat blastocysts.

By M. Buehr, Stephen Meek, Kathryn Blair, Jian Yang, J. Ure, José C. R. Silva, Renee McLay, John Hall, Qi-Long Ying, Austin G Smith. Cell, 2008

828 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/22c2f2241ca7e1ff007cb9f2b00ff9ad86694daf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Jennifer Nichols
2. Austin G Smith
3. José C. R. Silva
4. R. Jaenisch
5. J. Hanna
6. Krishanu Saha
7. M. Roode
8. G. Guo

Citations in the corpus

• Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, positive): “Explanted blastocysts from rats and ‘‘nonpermissive’’ mouse strains, such as nonobese diabetic (NOD) mice, yielded exclusively EpiSC-like pluripotent cells (Buehr et al., 2008; Hanna et al., 2009a).”
• Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs (2010, background): “To test whether conditions devised to stabilize mouse NOD and rat ESCs (5, 11, 12) influence the properties of human pluripotent stem cells in vitro, we utilized previously described C1 secondary human female fibroblasts (19) to derive hiPSCs under various culture conditions (Fig.”
• Klf4 reverts developmentally programmed restriction of ground state pluripotency (2009, background): “Recently, however, it has been established that small molecules that selectively inhibit the Mek/Erk MAP kinase signalling cascade and glycogen synthase kinase 3 (Gsk3) provide, in combination with Lif, an optimal environment for derivation and propagation of ES cells from different rodent backgroun”
• The Transcriptional and Epigenomic Foundations of Ground State Pluripotency (2012, background): “Use of 2i has enabled derivation of germline-competent ES cells from all mouse strains tested and for the first time from rats (Buehr et al., 2008; Hanna et al., 2009; Kiyonari et al., 2010; Li et al., 2008; Nichols et al., 2009).”
• Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo (2009, methodology): “The combination of PD0325901 with Chir99021, termed 2i, is very effective for propagating ES and induced pluripotent cells (Buehr et al., 2008; Silva, J. et al., 2008; Ying et al., 2008).”
• Naive and primed pluripotent states. (2009, methodology): “Rat ESCs capable of chimera contribution and germline transmission have finally been derived (Buehr et al., 2008; Li et al., 2008).”
• Molecular mechanisms and potential therapeutical targets in Huntington's disease. (2010, background): “Recent advancements in the stem cell field have led to the isolation of rat embryonic stem cells (87).”