How is pluripotency determined and maintained?

By H. Niwa. Development, 2007

851 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9353fbea18c9cfab09953bfa09ebd515adfdc193

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In Molecular Biology

Citations in the corpus

Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells (2008, background): “Transcription factors that control ES cell pluripotency and self-renewal have been identified (Chambers and Smith, 2004; Niwa, 2007 ), and a draft of the core regulatory circuitry by which these factors exert their regulatory effects on protein-coding genes has been described (Boyer et al., 2005; L”
Mechanisms of stem cell self-renewal. (2009, background): “Because overexpression of Oct4 leads to trophectodermal differentiation, this circuit also requires negative feedback (reviewed by Niwa 2007).”
Capture of authentic embryonic stem cells from rat blastocysts. (2008, neutral): “It is unclear whether ES cells themselves arise as a consequence of the synthetic culture milieu or represent a transient phase in ontogeny that is captured by arresting developmental progression (Buehr and Smith, 2003; Gardner and Brook, 1997; Niwa, 2007; Silva and Smith, 2008; Smith, 2001a).”
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “Not only can they directly activate and repress transcription but also they can control gene expression and the cell cycle by regulating epigenetic modifiers and microRNA”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “Consequently, a key role of these master regulators is probably to counteract differentiation by continuously suppressing expression and activity of lineage specification factors (reviewed in Niwa, 2007) (Figure 1.8).”
Naive and primed pluripotent states. (2009, background): “How extraembryonic lineage segregation is secured while pluripotency develops in adjacent cells are intertwined issues in preimplantation development (Niwa, 2007).”
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008, background): “ESCs have a globally relaxed, hyperdynamic chromatin structure (Niwa, 2007).”
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells (2007, background): “dtd" [ ]> Analysis of the molecular network that regulates the pluripotency of mouse ES cells has identified three transcription factors, Oct3/4, Nanog and Sox2, all of which are highly expressed in the inner cell mass, epiblast and undifferentiated ES cell”
DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells (2017, background): “Mouse embryonic stem cells (ESCs) from early-stage embryos have indefinite self-renewal capacity and can differentiate into cell types derivative of all three germ layers through asymmetric cell division (Niwa, 2007).”
An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “These functions are likely to include positive regulation of proliferation, negative regulation of differentiation, and regulation of chromosomal accessibility of other factors, as previously suggested (Niwa, 2007).”
Control of Embryonic Stem Cell State (2011, background): “In ESCs, the pluripotent state is largely governed by the core transcription factors Oct4, Sox2, andNanog (Table 1) (Chambers and Smith, 2004; Niwa, 2007; Silva and Smith, 2008).”