Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression

917 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Perturbations of the AKT signaling pathway in human cancer (2005, background): “AKT activation mediates cell cycle progression by phosphorylation and consequent inhibition of glycogen synthase kinase 3b to avert cyclin D1 degradation (reviewed in Liang and Slingerland, 2003).”
Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size (2005, background): “Akt has also been strongly implicated as a major regulator of the progression through the G1 and G2 phases of the cell cycle (41).”
Targeting phosphoinositide 3-kinase: moving towards therapy. (2008, background): “An increase in the levels of cyclin D1 and a reduction in p27 are the conditions required for the cells to pass the transition between G1 and S phase [60,61].”
Targeting PI3K/Akt/mTOR Signaling in Cancer (2014, background): “With regard to GSK3, Akt/PKB triggers a network that positively regulates G1/S cell cycle progression through inactivation of GSK3-β, leading to increased cyclin D1, and inhibition of the Forkhead family transcription factors and the tumor suppressor tuberin (TSC2), ultimately resulting in the reduc”
Integration of the extranuclear and nuclear actions of estrogen. (2005, background): “genes, such as cyclin D1 (61), contributing to carcino-”