Defensins: antimicrobial peptides of innate immunity

By T. Ganz. Nature reviews. Immunology, 2003

2,927 citations recorded by the source corpus.

Subfields: Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/235a55a10823281585fce26375d7909cbccdef62

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Microbiology

In Molecular Biology

Citations in the corpus

Of Mice and Not Men: Differences between Mouse and Human Immunology (2004, background): “These are important in mucosal defense in the gut and in epithelial defense in skin and elsewhere (12, 13).”
Myeloperoxidase: friend and foe (2005, neutral): “These include defensins, seprocidins, bactericidal/permeability-increasing protein, lysozyme, cathelicidins, phospholipase A2, and lactoferrin [339–342].”
Toll-like receptors and cancer (2009, background): “TLRs are involved in the transcriptional and post-transcriptional regulation (proteolytic processing and secretion) of potent antimicrobial factors such as defensins (α and β), phospholipase A 2 , lysozyme and the regeneration (Reg) family of molecule”
Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity (2016, background): “HDPs exhibit their properties as broad spectrum antimicrobials against bacteria, enveloped viruses, fungi, and protozoa by direct binding and lysis of microbial membranes (Ganz, 2003), which prevents the development of resistance to HDPs in pathogens.”
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection (2006, background): “Two main families of antimicrobial peptides in mammals, the defensins and the cathelicidins, are expressed in immune cells and at epithelial surface”
Stratum corneum defensive functions: an integrated view. (2005, background): “Defensins comprise small, cationic, and cysteine-enriched members of a highly conserved gene family, consisting of a and b subtypes, which differ slightly in their disulfide-bond pairing, genomic organization, and tissue distribution (Ganz, 2003).”
Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression1 (2004, background): “bial peptides (2, 3) that can fend off bacterial and viral”
Peptide Antimicrobial Agents (2006, background): “A second prominent group of mammalian antimicrobial peptides is the defensins (70, 221), cyclic peptides which are categorized into three subfamilies on the basis of the disulfide pairings between their six conserved cysteine residues ( - and -defensins) or their macrocyclic nature ( -defensins).”
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis (2011, background): “In mammals, defensins are a major family of antimicrobial peptide”
The Roles of Antimicrobial Peptides in Innate Host Defense (2009, background): “Although AMPs are commonly classified by variation in structural characteristics, there are some structural features that AMPs share, including a length of less than 60 amino acids, broadspectrum antimicrobial activity at physiological conditions, and an overall positive charge (reviewed in [6,19]).”
Interactions between commensal intestinal bacteria and the immune system (2004, background): “Systemic immune ignorance The physical barrier that separates the large numbers of commensal intestinal bacteria from the underlying tissues is only a simple (single cell) epithelial layer; although it is reinforced by a layer of mucus, the secretion of IgA and the production of antibacterial mol”