Interactions between commensal intestinal bacteria and the immune system

By A. Macpherson, N. Harris. Nature reviews. Immunology, 2004

1,615 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Food Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8f385b1d5e9aac70516434ef9cc9e1dc6581afdd

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Citations in the corpus

Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “Commensals are believed to promote the generation and maturation of organized gut-associated lymphoid tissues (GALTs) because they facilitate recruitment of immune cells to the mucosa [14].”
The gut microbiota regulates bone mass in mice (2012, background): “Studies have shown that germ-free (GF) animals have immature mucosal immune systems with hypoplastic Peyer’s patches containing few germinal centers and reduced number of IgA-producing plasma cells and lamina propria CD4þ T cells.((6)) Furthermore, GF mice have reduced number of CD4þ T cells in the ”
Access to mutualistic endosymbiotic microbes: an underappreciated benefit of group living (2008, background): “Studies with germ-free animals provide compelling evidence that endosymbionts are critical players in the development of the gut adaptive immune systems of their hosts (Macpherson and Harris 2004; Cash and Hooper 2005).”
Gut microbiota in health and disease. (2010, background): “tic Peyer’s patches (PP) (180) and a decreased number of”
Animal behaviour meets microbial ecology (2011, background): “…bacterial communities help them extract energy and nutrients from food (Nalepa 1994; Ley et al. 2008), produce vitamins (Hill 1997), fight pathogens (Fons et al. 2000; Dillon et al. 2005; Ruiz-Rodríguez et al. 2009) and train the immune system (Umesaki et al. 1999; Macpherson & Harris 2004).”
Evolution of the immune system in humans from infancy to old age (2015, positive): “Germ-free mice have immunological defects, including fewer Peyers patches, smaller lymphoid follicles and abnormal germinal centres in the small intestine lymphoid tissue [56].”
Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study (2006, background): “39 Nevertheless, it can be assumed that although the proportions and activities of the microbiota change with passage through the intestinal tract, most viable and non-viable intestinal bacteria will still be detectable in the faeces by molecular methods.”
RNA Viral Community in Human Feces: Prevalence of Plant Pathogenic Viruses (2005, background): “Given that nonpathogenic commensal intestinal bacteria can significantly alter the immune system of an organism [39], it is conceivable that viruses such as PMMV, replicating or not, may also have an effect.”
Disordered Microbial Communities in Asthmatic Airways (2010, background): “Commensal bacteria elicit tonic signals in the gut epithelium that prevent activation of innate and adaptive immune responses [28,29], and commensal bacteria down-regulate immune responses to pathogens in the nasal mucosa [30].”