Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

By C. Bevins, Nita H. Salzman. Nature Reviews Microbiology, 2011

1,168 citations recorded by the source corpus.

Subfields: Food Science, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/47512ef5e9cd96161aa162e957520b5549bbcfa9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

1. Patrice D Cani
2. W. D. de Vos
3. C. Belzer
4. M. Derrien
5. B. B. Finlay

In Microbiology

1. J. Rolff
2. B. B. Finlay
3. Robert E. W. Hancock

In Molecular Biology

1. Patrice D Cani
2. W. D. de Vos
3. C. Belzer
4. N. Delzenne
5. M. Derrien
6. A. Everard
7. G. Muccioli
8. Eran Elinav

Citations in the corpus

• Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. (2012, background): “Rather than remaining unresponsive, the host actively controls the microbiota composition by secretion of antimicrobial peptides and immunoglobulins (Bevins and Salzman, 2011; Peterson et al., 2007).”
• Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity (2013, methodology): “, α-defensins, lysozyme C, phospholipases, and C-type lectin, primarily the RegIIIγ) or enterocytes (RegIIIγ) (10, 12).”
• Interaction between microbiota and immunity in health and disease (2020, background): “The majority of intestinal AMPs is produced by Paneth cells, which represent specialized secretory cells of the small intestinal mucosa.(48) Intestinal AMPs exhibit manifold interactions with the microbiota and are an essential component in shaping its configuration.”
• Identification of antimicrobial peptides from the human gut microbiome using deep learning (2022, methodology): “We cross-checked with metaproteomics data to ensure the expression of potential peptides and further selected AMPs that were significantly negatively correlated to bacterial species in multiple metagenomic cohorts 29,49 , to select potential c_AMPs for follow-up functional studies.”
• Antimicrobial peptides: Application informed by evolution (2020, background): “In addition to combatting infectious pathogens, AMPs are used to regulate bacterial symbionts and communities in the gut and other tissues (49).”
• Mining the human gut microbiota for immunomodulatory organisms (2017, positive): “In GF mice, a-defensins, Reg3 family members, and other Paneth-cell-derived products (such as Ang4) were expressed at reproducibly high levels in the SI but at 20-fold lower levels in the colon (Figure 6A), where they were among the most variably expressed transcripts genome-wide (as indicated by th”