Peptide Antimicrobial Agents

By H. Jenssen, P. Hamill, Robert E. W. Hancock. Clinical Microbiology Reviews, 2006

2,409 citations recorded by the source corpus.

Subfields: Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/22d126593ca5b5474de9a3c26dd47e208247f2b2

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Citations in the corpus

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents (2016, background): “It is likely that the mode of action of individual AMPs varies depending on parameters such as peptide concentration, target bacterial species, as well as tissue localization and growth phase of the bacteria (Yeaman and Yount, 2003; Jenssen et al., 2006).”
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies (2006, background): “Several complex and controversial models describe these subsequent events, including the reorientation of peptide molecules perpendicular to the membrane to form either barrel-stave or toroidal channels, the breakdown of membrane integrity as a result of the swamping of membrane charge by a 'carpet'”
Antimicrobial Peptides (2013, background): “Even the AMPs with very similar structures can have drastically different mechanisms of action and the range of targeted cells [47].”
Endosomal escape pathways for delivery of biologicals. (2011, background): “Formation of toroidal pore model is mediated by aggregates of peptides which enter into the membrane in a perpendicular orientation followed by membrane curving inward to form a hole which the peptides line it [32].”
Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo (2018, background): “It is active against a variety of Gram-positive bacteria with a minimum inhibitory concentration (MIC) in the nanomolar range and has been used as a food preservative for 50 years with no significant development of resistance [2].”
MilkAMP: a comprehensive database of antimicrobial peptides of dairy origin (2014, background): “Although membrane interaction might be essential, alternative mechanisms are increasingly considered as components of AMP action against microbes (Jenssen et al. 2006).”
Antimicrobial peptides: key components of the innate immune system (2012, background): “The major issues that need attention are susceptibility of peptides to proteolytic enzymes, lack of information regarding antigenicity, immunogenicity, potential toxicities of relatively large and highly charged peptides, ability to achieve high microbicidal activity under physiological conditions a”
Strategies and molecular tools to fight antimicrobial resistance: resistome, transcriptome, and antimicrobial peptides (2013, background): “Although nonspecific targets led researchers to suggest that it would be difficult for the bacteria to develop resistance to some peptides (Ge et al., 1999a,b; Schroder, 1999; Zasloff, 2002; Boman, 2003; Jenssen et al., 2006), molecular mechanisms of resistance to CAMPs have been suggested in severa”
Multifunctional cationic host defence peptides and their clinical applications (2011, background): “As a result of their amphipathic nature, all AMPs interact directly with the cytoplasmic membrane of Gram-positive and Gram-negative bacteria, as well as eukaryotic microbes [ 43 ], leading to either membrane barrier disruption or to uptake and inhibition of intracellular targets.”
CAMP: a useful resource for research on antimicrobial peptides (2009, background): “In the past few years, antimicrobial peptides (AMPs) have attracted lot of attention as a substitute for conventional antibiotics (1).”
Intestinal microbiome of poultry and its interaction with host and diet (2014, background): “They are small cationic peptides produced by avian macrophages, heterophils, and epithelial cells, and they can kill various intestinal pathogens by disrupting cell membrane permeability, which leads to cell lysis.(57,58) Brisbin et al.”
Antimicrobial peptides: The ancient arm of the human immune system (2010, background): “, 100 mM monovalent or 2 mM divalent cations found at many body sites.(27) Nevertheless, the high concentrations of α-defensins in the granules of neutrophils and in the intestinal crypts are thought to be sufficient for direct killing of pathogens.”
Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. (2009, background): “Such peptides have broad spectra of activity that can encompass bacteria, fungi, viruses, and parasites (8).”
Mechanisms and consequences of bacterial resistance to antimicrobial peptides. (2016, background): “AMPs are produced by epithelial cells and by circulating immune cells including neutrophils and macrophages, and are among the first immune effectors encountered by an invading microbe (Jenssen et al., 2006).”