Of Mice and Not Men: Differences between Mouse and Human Immunology

By J. Mestas, C. Hughes. Journal of Immunology, 2004

3,762 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e27cfc4cc406533b9b58e5093065db25e32b4520

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In Immunology

Citations in the corpus

Arginase: an emerging key player in the mammalian immune system (2009, background): “The fundamental disrepancies of arginase expression and regulation between murine and human immune cells fit into a growing list of differences in the immune systems of both species (Mestas and Hughes, 2004).”
A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype (2010, background): “Whis this in mind, an explanation for the contrasting and complex immune modulating effects reported thus far for TLR activation in most stem cells may lie in reinterpretation of all of the data taking into account the fact that most of the current stem cell preparations yield heterogeneous pools of”
Genomic responses in mouse models poorly mimic human inflammatory diseases (2013, background): “There are multiple considerations to our finding that transcriptional response in mouse models reflects human diseases so poorly, including the evolutional distance between mice and humans, the complexity of the human disease, the inbred nature of the mouse model, and often, the use of single mechan”
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “…differences in the gene promoter in human NOS2 compared to mouse NOS2 result in the production of different NO levels by human microglia or peripheral macrophages compared to rodents (Colton et al. 1996; Ganster et al. 2001; Mestas and Hughes 2004; Snell et al. 1997; Weinberg et al. 1995).”
The functional network of ion channels in T lymphocytes (2009, neutral): “lymphocytes differ in their functional characteristics (246).”
A Comparative Encyclopedia of DNA Elements in the Mouse Genome (2014, background): “Indeed, previous studies have uncovered extensive differences in the immune systems among different mouse strains and between humans and mice 59 , ranging from relative makeup of the innate immune and adaptive immune cells 59 , to gene expression patterns in various immune cell types 60 , and…”
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. (2011, background): “At the microscopic level, murine lungs differ from human lungs in that they have a larger number of Clara cells in the distal airways; extensive bronchial-associated lymphoid tissue, and a virtual absence of submucosal glands beyond the proximal trachea (6).”