Toll-like receptors and cancer

By S. Rakoff-Nahoum, R. Medzhitov. Nature Reviews. Cancer, 2009

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How researchers see this paper

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Immunity, Inflammation, and Cancer (2010, neutral): “Oncogenic transcription factors can also be activated through pattern recognition receptors by components of bacteria and viruses (Rakoff-Nahoum and Medzhitov, 2009).”
Targeting Toll-like receptors: emerging therapeutics? (2010, background): “In the 19 th century William Coley observed the antitumour effect of repeated injections of toxins from dead Gram-positive bacterium Streptococcus pyogenes and Gram-negative bacterium Serratia marcescens (known as Coley's toxin”
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity (2015, background): “Inflammation has emerged as a major factor promoting cancer development (Coussens et al., 2013; Grivennikov et al., 2010; Mantovani et al., 2008; Rakoff-Nahoum and Medzhitov, 2009).”
Toll-Like Receptor Signaling Pathways (2014, background): “The innate immune activation that caused after anti-cancer drug treatment is reportedly critical for cancer elimination through TLR-mediated recognition of endogenous molecules released from dying cancer cells (80).”