A possible unifying principle for mechanosensation

By C. Kung. Nature, 2005

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MscS‐Like Proteins in Plants (2007, background): “The transient receptor potential (TRP) or degenerin/epithelial sodium channel (Deg/ENaC) families of MS ion channels are found in many animal cells and mediate the perception of pain, touch, and sound (Sukharev and Corey, 2004; Kung, 2005).”
Mechanisms of sensory transduction in the skin (2007, background): “The conceptual framework guiding these efforts posits that transduction channels are directly activated by mechanical stimul”
Central mechanisms of osmosensation and systemic osmoregulation (2008, background): “Actin filaments could serve as tethers that impart volume-dependent strain through physical links to the ion channel, or as scaffolds in specialized membrane domains in which untethered channels could experience shape-induced forces at the protein–lipid interfac”
Local force and geometry sensing regulate cell functions (2006, background): “, which often also involves conformational changes of their substrate”