Cellular mechanotransduction: putting all the pieces together again

By Donald E. Ingber. The FASEB Journal, 2006

1,629 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/26c95b7b23d91b80fcbc4a18347d802301ef5a98

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Citations in the corpus

A practical guide to hydrogels for cell culture (2016, background): “…of the material in culture and may also influence cellular mechanotransduction (the conversion of mechanical information from the microenvironment into biochemical signaling), which in turn has consequences for cellular behaviors like spreading, migration, and stem cell differentiation 15 .”
Mechanical control of tissue and organ development (2010, background): “…cytoskeleton are also resisted by these adhesive tethers to neighboring cells and the ECM, and by internal cytoskeletal structures that resist being compressed, such as microtubules or cross-linked actin filaments within filopodia (Wang et al., 2001; Brangwynne et al., 2006; Ingber, 2006).”
Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate. (2014, background): “On the exterior of the cell, integrins bind ECM protein ligands including collagen, laminin, and fibronectin [93].”
Cell mechanics: integrating cell responses to mechanical stimuli. (2007, positive): “force, these measurements are consistent with tensegrity models for cell mechanics, which emphasize the geometry of the networks and the interplay of tension and compression in cytoskeletal structure (148).”
Cell–matrix adhesion (2007, background): “For recent reviews see references Miranti and Brugge (2002); Danen and Sonnenberg (2003); Guo and Giancotti (2004); Wozniak et al. (2004); Ginsberg et al. (2005); Li et al. (2005);Mitra et al. (2005); Vicente-Manzanares et al. (2005); Janes and Watt (2006); Luo et al. (2007).”
Intermediate filaments: from cell architecture to nanomechanics (2007, background): “For this reason, one might assume that the number of effective interactions is high and probably beyond our ability to be appropriately describe”
Biosensing with plasmonic nanosensors. (2008, background): “Labelling proteins and ligands with nanoparticles thus provides a way to explore conformational changes and binding interaction”
Mechanotransduction gone awry (2009, background): “Cells need to feel the force All cells and organisms across the evolutionary spectrum, from the most primitive to the most complex, are mechanosensitiv”
Environmental sensing through focal adhesions (2009, background): “Thus, the focal adhesion mechanosensor might be regarded as a network of tightly interconnected molecular mechanosensing units that operate in a coordinated fashion in response to mechanical force”
On the nature of biomaterials. (2009, background): “Both Ingber [20] and Bao and Suresh [21] make similar types of arguments.”
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus (2009, background): “This occurs because the cell can tense, and thereby stiffen, load-bearing cytoskeletal filaments relative to surrounding regions of the cytoplas”