Trp ion channels and temperature sensation.

By A. Dhaka, Veena Viswanath, Ardem Patapoutian. Annual Review of Neuroscience, 2006

780 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/c76e34f2db32936c21a6451d02bdf2719557aa49

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Ardem Patapoutian
2. Clifford J. Woolf
3. A. Dhaka
4. B. Nilius
5. Taryn J. Earley
6. G. Owsianik
7. Matt J. Petrus
8. Jayanti Mathur

In Endocrine and Autonomic Systems

1. J. Scholz
2. Clifford J. Woolf

In Sensory Systems

1. Ardem Patapoutian
2. Clifford J. Woolf
3. B. Nilius
4. G. Owsianik
5. A. Dhaka
6. Taryn J. Earley
7. Jayanti Mathur
8. Matt J. Petrus

Citations in the corpus

• Transient receptor potential cation channels in disease. (2007, background): “The role of TRP channels in thermosensation has been the subject of several recent and extensive reviews to which the reader is referred (97, 240, 268, 334, 369).”
• Neuropathic Pain (2009, background): “8 Ectopic Impulse Generation . . . . . . . . 10 Ectopic Transduction . . . . . . . . . . . . . . 11 Central Sensitization . . . . . . . . . . . . . . . 11 Low-Threshold Aβ Fiber-Mediated Pain . . . . . . . . . . .”
• Transient receptor potential channels: targeting pain at the source (2009, background): “Six of the 28 TRP channels from the three distinct TRP family subtypes are activated by temperature (TRPV1–4, TRPM8 and TRPA1), and are expressed in sensory neurons or in skin keratinocyte cells, which are peripheral targets of these nerve”
• The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept (2007, background): “We also briefly discuss the salient features of other thermo transient-receptor-potential (thermoTRP) channel”
• Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines (2007, background): “[3 1 2] cycloaddition reaction between alkyne and azide groups (‘click chemistry’) (Fig.”
• TRPM8 is required for cold sensation in mice. (2007, positive): “Four TRP Vanilloid (TRPV) and three TRP Melastatin (TRPM) family members are activated by heat, and mouse knockout studies have demonstrated roles for three TRPV ion channels in innocuous and noxious heat sensation (reviewed in Dhaka et al., 2006 ).”
• Mechanisms of sensory transduction in the skin (2007, background): “In mammals, thermally sensitive TRPs are each tuned to a distinct temperature range and most are expressed in cutaneous sensory neurons or other cell types in ski”