Targeting death and decoy receptors of the tumour-necrosis factor superfamily

By A. Ashkenazi. Nature Reviews. Cancer, 2002

1,433 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0e769c58283046f54a53b13669c1d802240d22ee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

Citations in the corpus

Role of Bcl-2 family proteins and caspases in the regulation of apoptosis (2011, background): “Fas recruits Fas-associated death domain protein (FADD) whereas TNF-R recruits TNF-R1-associated death domain protein (TRADD) which again recruits FADD [7].”
The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges (2019, background): “Extrinsic apoptosis pathway is initiated by death receptors which are members of tumor necrosis factors (TNFs) that are capable of regulating cell fate [73].”
Histone deacetylase inhibitors: molecular mechanisms of action (2007, background): “HDACi activates the extrinsic apoptotic pathways The extrinsic pathway of apoptosis is initiated by the binding of death receptors, including Fas (Apo-1 or CD95), tumor necrosis factor (TNF) receptor-1 (TNFR-1), TNF-related apoptosis-inducing ligand (TRAIL or Apo2-L) receptors (DR-4 and -5), DR-3 (A”
The TRAIL apoptotic pathway in cancer onset, progression and therapy (2008, background): “The pathway involving TNF-related apoptosis-inducing ligand (TRAIL, also known as APO2L and TNFSF10 ) and TRAIL receptors (TRAILRs) is most promising, as preclinical models suggest that apoptosis of tumour cells is achievable in vivo without lethal toxicitie”
Promoting apoptosis as a strategy for cancer drug discovery (2005, background): “TRAIL The death receptors of the TNF superfamily represent potential targets for promoting apoptosis in cance”
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. (2009, positive): “…activated from within the cell by developmental cues or cellular damage (Zornig et al., 2001), and the extrinsic pathway, stimulated from the cell’s outside by specific proapoptotic ligands that belong to the tumor necrosis factor (TNF) superfamily (Ashkenazi, 2002; Peter and Krammer, 2003).”
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin (2005, background): “The significance of these considerations is not without precedence : the TNF receptor family , of which p75 NTR is a founding member , is well known to consist of decoy receptors that modulate the biological activity of the transmembrane coun - terparts ( for review , see Ashkenazi , 2002 ) .”
New aspects of natural-killer-cell surveillance and therapy of cancer (2002, background): “A large family of pleiotropic, cell-membrane-bound and secreted cytokines of the TNF family are also able to mediate apoptosi”
Ways of dying: multiple pathways to apoptosis. (2003, background): “It will be argued here that in stress-induced apoptosis, as in death receptor signaling (Strasser et al. 2000; Ashkenazi 2002), caspases can be activated upstream or independently of mitochondria, and hence that the mitochondrial breach may often simply deliver the coup de grace to a cell already on”
Molecular mechanisms of drug resistance (2005, background): “A more promising clinical approach may be to target the TRAIL receptors, as TRAIL has been shown to exert marked anti-cancer activity without systemic toxicity in mice [181].”
Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. (2003, background): “One approach is to engage the death receptors DR4 or DR5 with agonistic antibodies [121].”
Signalling pathways of the TNF superfamily: a double-edged sword (2003, background): “In the case of TRAIL, although DR4 and DR5 transduce most signals, DCR2 transduces partial signals onl”
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL (2007, background): “One approach aims to kill tumor cells by targeting the extrinsic apoptosis pathway through proapoptotic death receptor”
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (2006, background): “The idea to specifically target the extrinsic pathway to trigger apoptosis in tumor cells, for example by ligation of death receptors, is attractive for cancer therapy since death receptors have a direct link to the cell’s death machinery (Ashkenazi, 2002).”
Latent bone metastasis in breast cancer tied to Src-dependent survival signals (2009, background): “DR5 is expressed in our cell line systems and in bone metastases (Affymetrix HG-U133A raw intensity range 300–600 after MAS5.”