The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

By C. Loh, J. Chai, T. F. Tang, W. Wong, Gautam Sethi, M. Shanmugam, P. Chong, C. Looi. Cells, 2019

1,125 citations recorded by the source corpus.

Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metastasis and chemoresistance in cancer patients. The hallmark of EMT is the upregulation of N-cadherin followed by the downregulation of E-cadherin, and this process is regulated by a complex network of signaling pathways and transcription factors. In this review, we summarized the recent understanding of the roles of E- and N-cadherins in cancer invasion and metastasis as well as the crosstalk with other signaling pathways involved in EMT. We also highlighted a few natural compounds with potential anti-EMT property and outlined the future directions in the development of novel intervention in human cancer treatments. We have reviewed 287 published papers related to this topic and identified some of the challenges faced in translating the discovery work from bench to bedside.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/57d37d5e0d1c8063d3a29a2134d30c74c21d8654

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

  1. Yuhe Huang
  2. Xiawei Wei
  3. Weiqi Hong

In Oncology

  1. Yuhe Huang
  2. Xiawei Wei
  3. Weiqi Hong

Citations in the corpus