Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL

By K. Wagner, E. Punnoose, T. Januario, D. Lawrence, R. Pitti, Kate Lancaster, Dori Lee, M. Goetz, S. Yee, K. Totpal and 6 more. Nature Medicine, 2007

617 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8cadaeb8ca70bacf8121a8556d6f042587a55c12

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Zhaoyu Jin
2. M. Smyth
3. D. Lawrence
4. Jennie Lill
5. Yun Li
6. Victoria C. Pham
7. R. Pitti
8. A. Ashkenazi

In Molecular Biology

1. Zhaoyu Jin
2. D. Lawrence
3. M. Smyth
4. Jennie Lill
5. Yun Li
6. Victoria C. Pham
7. R. Pitti
8. A. Ashkenazi

Citations in the corpus

• Protein Glycosylation in Cancer (2015, background): “In addition, ppGalNAcT-14 is overexpressed in colorectal carcinoma and pancreatic cancer and is associated with altered sensitivity to TRAILinduced apoptosis through modulation of the O-glycosylation of death receptors on these tumor cells (138).”
• Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family. (2012, background): “2009) and GALNT14 to resistance to death-receptor-mediated apoptosis (Wagner et al. 2007).”
• Life and death by death receptors (2009, background): “Elevated expression of O-glycosyltransferases, the enzymes responsible for O-glycosylation of the receptors, correlates with sensitivity to TRAIL-mediated apoptosis in a large number of tumor cell lines, and represent a potential new biomarker to screen cancer patients for TRAIL-based clinical trial”
• Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. (2009, positive): “Alternatively, O-glycosylation of the extracellular domains of DR4 and DR5 facilitates ligand-induced receptor clustering (Wagner et al., 2007).”
• A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. (2009, background): “Cell line Cell line APO2L/TRAIL sensitivity: top 10% overexpressed in highly sensitive (Wagner et al., 2007) 86 13.”
• The TRAIL apoptotic pathway in cancer onset, progression and therapy (2008, background): “This whole-genome screen indicated that genes encoding enzymes that initiate and carry out O -glycosylation, such as GALNT14 , GALNT3 , FUT6 and FUT3 , were significantly overrepresented in TRAIL-sensitive cell line”
• Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions (2013, methodology): “Finally, we used CRC cell line data from the Cancer Cell Line Encyclopaedia4 (CCLE, n = 55, GSE36133) and from Wagner et al.33 (n = 11, GSE8332).”