Promoting apoptosis as a strategy for cancer drug discovery

By Stephen W. Fesik. Nature Reviews. Cancer, 2005

1,022 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/074c72e51d3b686433af7f74afd05c6dcf9b0b96

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Citations in the corpus

The BCL-2 protein family: opposing activities that mediate cell death (2008, background): “This review covers recent insights into the biochemical, cellular and physiological roles of the BCL-2 family without reiterating the roles of these proteins in cancer and drug development, which have recently been expertly reviewe”
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. (2006, neutral): “p53 and Bax) [233,234].”
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. (2007, background): “An alternative approach to the treatment of cancer, therefore, would be to reestablish the cell death program and set conditions such that cells can undergo apoptosis given an appropriate stimulus (Fesik, 2005).”
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. (2006, background): “Consequently, an attractive approach for anticancer therapeutics is to overcome this inherent resistance to apoptosis by directly activating the normal cell death machinery (Fesik, 2005).”
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL (2007, background): “100 1,000 100 75 50 25 NTC siC8 siGALNT14 (1) siGALNT14 (2)”
The TRAIL apoptotic pathway in cancer onset, progression and therapy (2008, background): “Apoptosis can be induced by various stimuli, and radiation or chemicals in particular have been used in cancer therap”
Metastasis: a question of life or death (2006, background): “We are just beginning to see the fruits of years of research on cell death, with the development of efficacious new molecules that target the apoptotic pathwa”
Role of autophagy in cancer (2007, background): “Indeed, BCL2 antagonists have entered the clinic as part of the armamentarium to functionally restore the apoptotic pathway to resistant tumour”
BCL-2 family antagonists for cancer therapy (2008, background): “Indeed, BCL-2 overexpression has since been reported in many tumour types and is often correlated with poor surviva”
Combining Immunotherapy and Targeted Therapies in Cancer Treatment (2012, background): “IAP inhibitors were originally developed to counteract the role of IAPs in blocking caspase activation, thereby sensitizing cancer cells to death stimul”
CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway (2008, background): “…the Akt/PKB and Bcl-2 survival pathway The evasion of programmed cell death is now recognized as one of the six essential alterations in cell physiology that dictate malignant growth and has been proven to be a hallmark of most, if not all, types of cancer (Hanahan and Weinberg, 2000; Fesik, 2005).”
Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “In this model system, PTEN inactivation was associated with increased angio-genesis—a close parallel to the progression of high-grade disease in humans coincident with loss of PTEN (Xiao et al. 2002, 2005).”
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. (2008, background): “Thus, a variety of approaches to target these oncoproteins have been pursued to restore the natural process of programmed cell death (3).”