New aspects of natural-killer-cell surveillance and therapy of cancer

By M. Smyth, Y. Hayakawa, K. Takeda, H. Yagita. Nature Reviews. Cancer, 2002

782 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/784dd1b9ff1806a5853a9b526369f17d9cd84d5a

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In Oncology

Citations in the corpus

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β11 (2009, background): “However, the functions of NK cells are usually impaired in cancer patients (23), and tumors can escape NK cell-mediated cytotoxicity through their mechanisms of immune escape such as secretion of inhibitory cytokines and shedding of soluble ligands for activating receptors (24).”
Targeting natural killer cells and natural killer T cells in cancer (2012, background): “imatinib mesylate (Gleevec®) First of its class Tyrosine Kinase Inhibitor (TKI), with clinical activity against Chronic Myeloid Leukaemia (CML) associated with the t(9;22) reciprocal translocation.”
CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review (2018, background): “In addition, IL‐12 exerts antimetastatic effects under the influence of IFN‐γ (Smyth et al., 2002).”
NK cells and cancer immunosurveillance (2008, background): “Cytokines, such as interleukin (IL)-2, IL-12, IL-15, IL-21 and IFN-a/b, enhance the activation state of NK cells or promote NK maturation, thereby augmenting NK cytolytic activity against tumour cells (Biron et al., 1999; Smyth et al., 2002, 2004; Nutt et al., 2004).”
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. (2008, background): “Intestinal NKp46 Cells Fail to Express Typical NK Cell Effector Functions NK cells employ several mechanisms to eliminate stressed or transformed target cells, including granule-mediated cytotoxicity and activation of Fas-associated protein with death domain (FADD)-linked death receptors (Smyth et a”
The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans (2009, background): “They are also an important part of the innate immune system as they directly kill transformed and virally infected cells (Smyth et al., 2002; Lanier, 2005; Yokoyama, 2008).”