Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.

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The Role of Autophagy in Cancer: Therapeutic Implications (2011, background): “Recent findings suggest a link between autophagy and the extrinsic apoptotic pathway that is mediated by p62/SQSTM 1 (77).”
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells (2011, background): “Growing lines of evidence indicate that p62 is a scaffold protein for cell survival and death-signaling pathways such as the NF-B pathway (Sanz et al., 1999; Moscat et al., 2007; Moscat and Diaz-Meco, 2009), Wnt signaling (Gao et al., 2010), and apoptosis (Jin et al., 2009).”
Cellular mechanisms controlling caspase activation and function. (2013, background): “Interestingly, caspase-8 activity appears to be enhanced within these aggregated foci, perhaps through increased stability of cleaved capase-8 (Jin et al. 2009).”