Signalling pathways of the TNF superfamily: a double-edged sword

By Bharat B. Aggarwal. Nature reviews. Immunology, 2003

2,873 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8a656d910b7128aa30320c7d12e8369b04c5f829

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Citations in the corpus

The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. (2007, background): “Of note, studies have indicated the presence of an important cross-talk between the two receptors, which is likely to be responsible for the net response of a cell upon TNF-a stimulation (28).”
Lymphoid organ development: from ontogeny to neogenesis (2006, background): “These cytokines are members of a 'superfamily' of proteins comprising at least 19 ligands and 29 receptors that have many biological activities associated with cancer, infectious disease, allergy, autoimmunity, transplantation biology and lymphoid organ developmen”
MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits. (2005, background): “Activation of receptors triggers major intracellular signalling pathways: mitogenactivated protein kinase (MAPK) pathways [26–29], and the pathway leading to activation of the transcription factor nuclear factor kappa B (NF nB) [26,30].”
Regulation of tumour necrosis factor signalling: live or let die (2015, background): “However, based on its structure, TNFR1 is classified as a death receptor and classical apoptosis was shown to occur upon TNF binding to TNFR1 (REFS 2,3) .”
Inflammation and cancer: how hot is the link? (2006, background): “However, when dysregulated and secreted in the circulation, TNF-a can mediate a wide variety of diseases, including cancer [17].”
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. (2007, background): “TNFa is a pleiotropic ligand of tumor necrosis factor receptor 1 and 2 (TNFR1 and TNFR2) that can signal both cell survival and cell death (Aggarwal, 2003; Bhardwaj and Aggarwal, 2003; Wajant, 2003).”
Essential function for the kinase TAK1 in innate and adaptive immune responses (2005, positive): “dtd" [ ]> Proinflammatory cytokines such as tumor necrosis factor (TNF) and interleukin 1β (IL-1β) have a critical function in innate immune responses by eliciting inflammatio”
Molecular targets of dietary agents for prevention and therapy of cancer. (2006, background): “Tumor necrosis factor (TNF), initially discovered as a result of its antitumor activity, has now been shown to mediate tumor initiation, promotion, and metastasis (for references see [145]).”
Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factorα Signaling during Peripheral Organ Inflammation (2009, background): “TNF signaling via TNF receptor 1 (TNFR1) is required for these observed effects since in TNFR1 deficient mice with hepatic inflammation, microglial expression of MCP-1/CCL2 and cerebral monocyte recruitment were both markedly inhibited, whereas there was no inhibition in TNFR2 deficient mice.”