ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming.

By É. Segura, C. Nicco, Bérangère Lombard, P. Véron, G. Raposo, F. Batteux, S. Amigorena, C. Théry. Blood, 2005

626 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fe8431e472c1e721336fb033af001bf2c17cbca4

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Citations in the corpus

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C (2010, background): “The proteins found in our exosome preparation were compared with proteins identified previously in exosomes from other cell types (Barile et al., 2005; Segura et al., 2005; Aoki et al., 2007; Valadi et al., 2007; Conde-Vancells et al., 2008).”
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells (2007, result): “The electron micrographs of the exosomes revealed rounded structures with a size of approximately 50–80 nm, similar to previously described exosome”
Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “…containing ICAM-1 and B cells-derived exosomes containing MHC Class I and II molecules, co-stimulatory molecules (CD80 and CD86) and ICAM-1 were shown to promote antigenpresenting function in recipient immune cells (Clayton et al., 2001; Théry et al., 2001; André et al., 2004; Segura et al., 2005).”
Membrane vesicles as conveyors of immune responses (2009, background): “In the case of DCs, the extent of exosome secretion varies during their life cycle: LPS-matured DCs secrete fewer exosomes than immature DCs (25–75% reduction”
Extracellular Vesicles: Unique Intercellular Delivery Vehicles. (2017, background): “(B7-1) and CD86 (B7-2) [72] or directly by ICAM-1-presenting mature DC-derived EVs [73].”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “For instance, we can cite a specific role of LFA-1 on DCs to capture ICAM-1-bearing DC-EVs (Segura et al. 2005), or a partial inhibition of DC-EV capture by DCs by antibodies blocking either LFA-1, ICAM-1, αv or β3 integrins, or CD9 or CD81 tetraspanins (Morelli et al. 2004).”
Exosomes: a common pathway for a specialized function. (2006, background): “The presence of I-CAM1 in exosomes from mature DCs appears to be essential for an indirect stimulation of T cells (49).”
Exosomes and other extracellular vesicles in host–pathogen interactions (2014, positive): “Several exosome surface ligands and adhesion molecules have been identified, including MFG-E8/lactadherin, tetraspanins, ICAM1 and phosphatidylserine [22,90,91].”
Exosomes in cancer: small particle, big player (2015, background): “Although the specific receptors that mediate the uptake of exosomes have not been found, there are several proteins that may act as potential receptors for exosome uptake, such as Tim1/4 for B cells [13] and ICAM-1 for APCs [14].”
Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses (2011, background): “For instance, exosomes secreted by mature DCs are more efficient to induce T-cell activation in vitro than those of immature DCs (44,50,51), and induce in vivo effector T-cell (50) and antibody responses (52).”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “Maturation of APCs can lead to increased levels of co-stimulatory molecules on the released EVs (459,460).”