Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

By H. Valadi, K. Ekström, A. Bossios, M. Sjöstrand, James J. Lee, Jan Lötvall. Nature Cell Biology, 2007

12,184 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e56b8802f50f8ee7dbef71b588576919187ab261

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Citations in the corpus

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, positive): “growing evidence for enrichment of certain RNA species in specific vesicle types (1,17,18).”
Mechanisms of mesenchymal stem/stromal cell function (2016, background): “[154] made a key contribution when they demonstrated that both mRNA and miRNA could be exchanged between cells by virtue of exosomal transfer.”
Membrane vesicles as conveyors of immune responses (2009, background): “Similarly, RNA present in mouse mast cell-derived exosomes can be transferred and transcribed into mouse proteins in human mast cell”
Hypoxic enhancement of exosome release by breast cancer cells (2012, background): “Exosomes contain a wide range of functional proteins, mRNAs and microRNAs (miRNAs) [3-5], providing a novel paracrine”
Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer* (2014, background): “However, the presence of DNA in exosomes is largely undetermined (21).”
Circulating miRNAs are correlated with tumor progression in prostate cancer (2011, background): “Recently, it was shown that the interaction between cells via mRNA and miRNA can be accomplished by microvesicle transfer.(26) Circulating miRNAs are proposed to be released from tumor cells in microvesicles to ensure communication with recipient cells in the surrounding microenvironment: Skog et al”
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. (2014, background): “This expands BrCa subpopulations adept at resisting therapy and reinitiating tumor growth.”
Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. (2011, background): “Beside mRNAs, MVs were shown to contain and to deliver functional miRNAs to target cells (9, 20).”
Endosome maturation (2011, background): “A similar process has, interestingly, been proposed for the inclusion of certain RNAs into ILVs (Valadi et al, 2007; Gibbings and Voinnet, 2010).”