Exosomes in cancer: small particle, big player
By Xu Zhang, Xiao Yuan, Hui Shi, Lijun Wu, Hui Qian, Wenrong Xu. Journal of Hematology & Oncology, 2015
734 citations recorded by the source corpus.
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs from one cell to another, leading to the exchange of genetic information and reprogramming of the recipient cells. Increasing evidence suggests that tumor cells release excessive amount of exosomes, which may influence tumor initiation, growth, progression, metastasis, and drug resistance. In addition, exosomes transfer message from tumor cells to immune cells and stromal cells, contributing to the escape from immune surveillance and the formation of tumor niche. In this review, we highlight the recent advances in the biology of exosomes as cancer communicasomes. We review the multifaceted roles of exosomes, the small secreted particles, in communicating with other cells within tumor microenvironment. Given that exosomes are cell type specific, stable, and accessible from body fluids, exosomes may provide promising biomarkers for cancer diagnosis and represent new targets for cancer therapy.
Subfields: Cancer Research, Materials Chemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/de2dbd59dbc5eeaedc2bccb4883ed8cf03c379a2
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Citations in the corpus
- Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma (2015, background): “Thus, the use of exosomes as biological delivery vehicles is of considerable interest [21, 22].”
- Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “By contrast, T lymphocytes do not seem to be very efficient in internalizing EVs, and the predominant mechanism for delivering their message into these cells is mediated through their interaction with cellular surface proteins that trigger intracellular signaling and provoke the T cell response (35”
- The biology and function of exosomes in cancer. (2016, background): “Alternatively, proteins present on the surface of the exosomes can engage cell surface receptors on recipient cells to induce intracellular signaling (19, 21, 22).”
- Exosome Theranostics: Biology and Translational Medicine (2018, background): “Exosome secretion occurs naturally, and cellular stress and activation signals can modulate the involved processes [15].”
- Exosomes as a new frontier of cancer liquid biopsy (2022, methodology): “The process of exosome biogenesis involves invagination of plasma membrane, formation of multivesicular bodies (MVBs) and exosome secretion [28].”
- Tumor-derived exosomes and their role in cancer progression (2016, background): “Since exosomes carry tissue factor (Tf) and can interact with components of the coagulation cascade [146], they are prime suspects in contributing to VTEs.”