Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

By Chieh Hsu, Y. Morohashi, S. Yoshimura, Natalia Manrique-Hoyos, Sangyong Jung, M. Lauterbach, Mostafa Bakhti, M. Grønborg, W. Möbius, J. Rhee and 2 more. Journal of Cell Biology, 2010

829 citations recorded by the source corpus.

A screen in oligodendrocytes establishes a Rab family member and its GAPs as regulators of exosome secretion by controlling endocytic vesicle docking with the plasma membrane.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a68e4367f9225b175d15a647756e5acb0334e228

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Citations in the corpus

SORTING IT OUT: REGULATION OF EXOSOME LOADING (2014, background): “Rab4, Rab5, Rab11, Rab35, Rab27a and Rab27b have been implicated in different steps of exosome release on different cell types [82-85].”
Exosomes and other extracellular vesicles in host–pathogen interactions (2014, positive): “More recent studies have implicated Rab35 in mediating MVB docking to the plasma membrane in neuralgia cells, where depletion of Rab35 resulted in a significant loss in exosome release [48].”
Exosomes: secreted vesicles and intercellular communications (2011, background): “Indeed, depending on the cell types, different molecules have been described in the biogenesis and secretion of exosomes: Rab11 in erythroleukemia cell lines [33], Rab27 in Hela cells [34], and Rab35 and neutral sphingomyelinase in oligodendroglial cells [35,36].”
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication (2013, background): “Previous work has demonstrated that Rab35 regulates exosome secretion from oligodendrocytes [29].”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “Release of exosomes through fusion of the MVB with the plasma membrane facilitated by RAB11 and RAB35 was first found when screening with dominate-negative Rab GTPase mutants (Savina et al. 2003; Hsu et al. 2010).”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “…of small GTPases from the Rab family play a role in the intracellular trafficking of MVEs toward either the plasma membrane (Savina et al., 2005; Hsu et al., 2010; Ostrowski et al., 2010) or to lysosomes for degradation (Stenmark, 2009), as well as cytosolic calcium levels (Savina et al., 2003;…”
Endosome maturation (2011, background): “In oligodendrocytes, Rab35 and its GAPs, TBC1D10A-C have been implicated (Hsu et al, 2010).”