Membrane vesicles as conveyors of immune responses

By C. Théry, M. Ostrowski, É. Segura. Nature reviews. Immunology, 2009

3,893 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bde7d5d4ed0ad97f3d9234c547a53142283dbce4

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Citations in the corpus

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes (2014, positive): “Exosomes are 50–100 Zm bi-lipid membrane vesicles with a protein- and RNA cargo, and they are actively secreted by many cell types [16,17].”
Exosomes in cancer development, metastasis, and immunity (2019, background): “Exosomes arise from the membranes of multivesicular bodies (MVB) [1, 2] and are cup-shaped in morphology under electron microscopy, with diameters ranging from 50 nm to 150 nm [3].”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “Another release process involves the inward budding of the endosomal membrane, resulting in the formation of multivesicular bodies (MVBs), with exosomes released by fusion of the outer MVB membrane to the plasma membrane (Théry et al. 2009; Denzer et al. 2000).”
Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “We developed a new drug delivery system for different therapeutic proteins, where macrophages were transfected with plasmid DNA (pDNA) encoding therapeutic proteins, catalase [113], or glial cell-line derived neurotropic factor (GDNF) [110] to treat neurodegenerative disorders.”
Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. (2012, background): “This revealed cup-shaped, 30–100 nm diameter structures that are typical of exosomes (Théry et al., 2009).”
Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. (2014, background): “The distinction between the various types of vesicles can be ascertained partly from their density [39].”
Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis (2011, neutral): “4 They may therefore be useful as prognostic and diagnostic biomarkers for early detection of a wide variety of diseases and have a potential role in monitoring treatment.”
Isolation of Extracellular Vesicles: General Methodologies and Latest Trends (2018, background): “), phosphatidylethanolamine, and phosphatidylserine [5, 10, 11].”
In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior (2015, background): “Tumor cells also release a wide variety of EVs (Bobrie and Théry, 2013; Théry et al., 2009), the cargo of which can potentially be used as biomarkers (Balaj et al., 2011; D’Souza-Schorey and Clancy, 2012; Skog et al., 2008).”
Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model (2017, background): “Exosomes—membrane-bound vesicles from 30 to 150 nm in diameter [21] produced by almost all cell types—may be critical for cell–cell communication [22].”
Exosome Theranostics: Biology and Translational Medicine (2018, background): “Apoptotic bodies and microvesicles are generated from the plasma membrane by direct budding and exist in a broad range of dimensions (apoptotic bodies, 800–5000 nm; microvesicles, 200–1000 nm [24, 25]), whereas exosomes are vesicles of endocytic origin with a diameter of 30–150 nm [26-28].”
Biodistribution and Delivery Efficiency of Unmodified Tumor-Derived Exosomes (2014, background): “, [64] and Robbins et al.”