Nonredundant roles for Stat5a/b in directly regulating Foxp3.
By Zhengju Yao, Y. Kanno, M. Kerenyi, G. Stephens, L. Durant, W. Watford, A. Laurence, G. Robinson, E. Shevach, R. Moriggl and 3 more. Blood, 2007
610 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/fb382dc0e6aaa8020a14c02ead48c6904fc5cead
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Alexander Y. Rudensky
- Shimon Sakaguchi
- Steven Z. Josefowicz
- E. Shevach
- Li-Fan Lu
- J. O’Shea
- C. Hsieh
- C. Lio
In Oncology
- E. Shevach
- J. O’Shea
- A. Laurence
- Y. Kanno
- Steven Z. Josefowicz
- P. Murray
- P. Krammer
- Shimon Sakaguchi
Citations in the corpus
- Regulatory T cells: how do they suppress immune responses? (2009, background): “IL-2 may also be required for Treg activation because IL-2 up-regulates Foxp3 expression via signal transducer and activator of transcription 5 (STAT5) (59, 60 ).”
- Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis (2010, background): “These findings indicate that although expression of these genes is decreased in a STAT3-dependent manner, they remain poised for transcription.”
- An essential role for IL-2 receptor in regulatory T cell function (2016, neutral): “Irf8 Cxcl10 Cd200 Cxcr6 Tox Il1r2 Rhoc Vim Actr3b Frmd5 Myo6 Drc1 Lgals1 Lama5 Itgb7 Selplg Cd47 Itgb3 Ptafr F2r Tnfsf8 Il9r Il1rl1 Klrg1 Socs2 Cish Expression (log2 fold) Stat5bCA Treg / control Treg Expressed (10,589) Act up (390): P < 2.”
- Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. (2007, methodology): “Binding of STAT5 to the Foxp3 promoters was used as a control (data not shown; Yao et al., 2007).”
- Regulatory T cells and immune tolerance. (2008, background): “Second , T cell-specific deficiency of STAT5a and b, which mediate signaling from the IL-2R β chain to the nucleus, abrogates the development of Foxp3 + Tregs, producing autoimmune/inflammatory disease (Burchill et al., 2007; Yao et al., 2007).”
- New insights into the regulation of T cells by γc family cytokines (2009, neutral): “By contrast, γ c -deficient ( Il2rg −/− ) mice and Jak3 −/− mice, in addition to having very low numbers of T cells, are devoid of FOXP3 + T Reg cell”
- Development and maintenance of regulatory T cells. (2013, background): “This region is also bound by Foxp3, Gata-3, and STAT5 in Treg cells, either directly or indirectly, and targeted deletion of the Foxp3 CNS2 region or Gata3 in Treg cells results in reduced transcription activity of Foxp3 (Rudra et al., 2012; Yao et al., 2007; Zheng et al., 2010).”
- Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “For example, STAT3 was described to mediate downregulation of Foxp3, and intriguingly, STAT3 is activated by several cytokines which negatively regulate Tregs and Foxp3, such as IL-6, IL-23, or IL-27 (Yang et al., 2007, 2008; Yao et al., 2007; Huber et al., 2008; Ahern et al., 2010).”
- Cytokine signaling modules in inflammatory responses. (2008, background): “Yoshimura and colleagues also showed that when Socs3 was absent, IL-6 via gp130-mediated Stat3 activation induces an anti-inflammatory response identical to the IL-10R, a finding that has since been confirmed with multiple experimental approaches (El Kasmi et al., 2006; Yasukawa et al., 2003).”
- A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells (2008, background): “Furthermore, it remains possible that additional signaling pathway”
- Differentiation of Effector CD4 T Cell Populations (2010, neutral): “STAT5 may contribute to Foxp3 induction by binding to its promoter (127, 129).”